Premature Birth clinical trials at UCSF
7 in progress, 2 open to eligible people
Premature birth happens when a baby is born too soon, before 37 weeks. UCSF is researching if a drug called bevacizumab can treat severe eye issues in early-born babies. UCSF is also developing a decision support tool for parents facing life support options for premature infants.
Bevacizumab Treatment For Type 1 ROP
open to eligible people ages up to 6 months
Type 1 retinopathy of prematurity in zone I represents the most severe type of ROP and has the worst prognosis. It is unknown whether low-dose bevacizumab will be successful in these severe cases. Also unknown is the timing and extent of peripheral…
San Francisco, California and other locations
Periviable GOALS Decision Support Tool
open to eligible people ages 18 years and up
The Periviable GOALS (Getting Optimal Alignment around Life Support) decision support tool (DST) is meant to facilitate informed shared decision-making regarding neonatal resuscitation for families facing the threat of a periviable delivery…
San Francisco, California and other locations
Milk, Growth and Microbiota Study
Sorry, currently not accepting new patients, but might later
Late preterm infants, who are born at 34, 35 or 36 weeks gestation, often have difficulty feeding, establishing growth, and fighting off infection. Breastfeeding provides improved nutrition to help fight infection, in part because breast milk…
San Francisco, California
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
Sorry, not yet accepting patients
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin daily. The study drug…
San Francisco, California and other locations
MARY-JANE Cannabis and Heart Rhythm Trial
Sorry, in progress, not accepting new patients
Despite recreational cannabis now being legal in 23 states, where more than 100 million Americans reside, studies on the actual health effects are limited. This study is a randomized trial, where each participant will be instructed to consume or…
San Francisco, California and other locations
Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
Sorry, in progress, not accepting new patients
Primary objectives of the study are: - To evaluate binocular visual acuity at the end of this study in patients included from the VGFTe-ROP-1920 study, for treatment of Retinopathy of Prematurity (ROP). - To evaluate long-term safety outcomes in…
San Francisco, California and other locations
Heart Rhythm Twins Study
Sorry, in progress, not accepting new patients
Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) are observed in the majority of individuals monitored for more than a few hours. Although the clinical course of PACs and PVCs is usually benign, it has been…
San Francisco, California
Our lead scientists for Premature Birth research studies include Miriam Kuppermann, PhD, MPH Mary Norton, MD Valerie Flaherman, MD, MPH Gregory Marcus.
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