Anaplastic Pleomorphic Xanthoastrocytoma clinical trials at UCSF

1 research study open to eligible people

Anaplastic pleomorphic xanthoastrocytoma is a rare type of brain tumor. UCSF is studying how well the drugs dabrafenib and trametinib work after radiation therapy in patients with high-grade glioma. These trials are now recruiting new patients.

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  • Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

    open to eligible people ages 3-25

    This phase II trial studies how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high grade glioma who have a genetic change called BRAF V600 mutation. Radiation therapy uses high energy rays to kill tumor cells and reduce the size of tumors. Dabrafenib and trametinib may stop the growth of tumor cells by blocking BRAF and MEK, respectively, which are enzymes that tumor cells need for their growth. Giving dabrafenib with trametinib after radiation therapy may work better than treatments used in the past in patients with newly-diagnosed BRAF V600-mutant high-grade glioma.

    San Francisco, California and other locations

Our lead scientists for Anaplastic Pleomorphic Xanthoastrocytoma research studies include .

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