Anesthesia clinical trials at UCSF
5 research studies open to eligible people
Anesthesia is used to keep patients pain-free during surgery. UCSF is running several clinical trials on anesthesia. One study focuses on reducing lung complications after surgery. Another trial compares different sedation techniques for cataract operations.
Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
open to eligible people ages 18 years and up
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of hospitalization. The objective of the study is to develop and implement perioperative strategies to eliminate PPCs in abdominal surgery, the field with the largest absolute number of PPCs. We will conduct a randomized controlled pragmatic trial in 750 studied participants. The effectiveness of an individualized perioperative anesthesia-centered bundle will be compared to the usual anesthetic care in patients receiving open abdominal surgery. At the end of this project, the investigators expect to change clinical practice by establishing a new and clinically feasible anesthesia-centered strategy to reduce perioperative lung morbidity. The research will be conducted across 14 US academic centers, and will be funded by the National Institute of Health.
San Francisco, California and other locations
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
open to eligible people ages 65 years and up
The goal of this pilot clinical trial comparing two different sedation approaches for cataract surgery is to assess patient satisfaction, the quality of recovery, and surgical outcomes as well as to evaluate the overall feasibility and acceptability of the study protocol for the purpose of planning a larger clinical trial. Participants will be asked to respond to several surveys throughout the study on their experience and to assess outcomes of interest.
San Francisco, California
Pupillometry as Guide for Extubation Readiness in Anesthetized Children
open to eligible people ages 2-10
Investigation of pupillometry as guide for extubation readiness in anesthetized children.
Oakland, California
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
open to eligible people ages 18 years and up
The investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
San Francisco, California and other locations
Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry
open to eligible females ages 15-55
The SOAP registry is a prospective, multicenter, electronic registry. The goal is to investigate the indications, mode of airway management, predisposing factors, and obstetric and anesthetic outcomes of pregnant patients who receive general anesthesia for cesarean delivery.
San Francisco, California and other locations
Our lead scientists for Anesthesia research studies include Matthieu Legrand, MD Catherine L Chen, M.D. Jeremy Juang, MD Won Lee, MD Daniel Abelson, MD.
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