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Anesthesia clinical trials at UCSF
5 in progress, 5 open to new patients

  • Anesthesia Depth And Postoperative Delirium Trial 2

    open to eligible people ages 64 years and up

    There is recent, but limited evidence to suggest that anesthetic depth is associated with poor postoperative cognitive outcomes. Specifically, several studies suggest that deeper level of anesthesia is associated with increased incidence of postoperative delirium and longer-term cognitive decline. In fact, some suggest that older patients undergoing surgery should routinely be monitored with an anesthetic depth monitor to allow the titration of anesthetics or sedation medications to lighter levels to promote better postoperative cognitive outcomes. However, such a practice has never been validated or proven to be feasible or safe. Accordingly, the investigators plan an exploratory study to determine the feasibility and safety of randomizing patients undergoing major surgery to receive deep vs. light anesthetic levels during surgery.

    San Francisco, California

  • Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery

    open to eligible people ages 18 years and up

    The aim of this study is to assess the incidence of postoperative pulmonary complications in patients undergoing mechanical ventilation during general anesthesia for robotic surgery, to characterize current practices of mechanical ventilation and to evaluate a possible association between ventilatory parameters and postoperative pulmonary complications.

    San Francisco, California and other locations

  • Cognitive Effects of Anesthesia on Children

    open to eligible people ages 6-11

    Anesthesia for more than 120 minutes given to children less than 2 years of age without coexisting diseases of the central nervous system or the heart cause long-term impairment of recognition memory.

    Oakland, California and other locations

  • Esophageal Manometry During Recovery From Anesthesia: Pilot Study

    open to eligible people ages 18-70

    1. An intact pharyngoesophageal reflex is essential to protect the upper airway from aspiration of either mouth contents or regurgitated gastric refluxate. This reflex is essential at protecting the airway in all patients. 2. In patients, while under general anesthesia, it is postulated that an identifiable upper esophageal sphincter and esophageal peristalsis are not present. 3. With the cessation of general anesthetics, accompanied by the reversal of nerve block, normal pharyngoesophageal peristaltic activity correlates with awakening the patient from anesthesia. This would be identified by the performance of esophageal manometry. 4. A return of normal verbally stimulated pharyngoesophageal swallowing sequence accurately identifies a safe time to remove endotracheal tubes and/or reverse anesthesia. This verbally stimulated swallowing sequence correlated precisely with the return of objective pharyngoesophageal function.

    San Francisco, California

  • Perioperative Virtual Reality for Pediatric Anesthesia

    open to eligible people ages 5-12

    The goal of this study is to evaluate the use of immersive audiovisual distraction and virtual reality to reduce perioperative anxiety in pediatric patients undergoing surgery at UCSF Benioff Children's Hospital. The study plans to employ virtual reality headsets during induction of anesthesia in pediatric patients for elective surgery in a randomized clinical trial.

    San Francisco, California