Autoimmune Disease clinical trials at UCSF

9 in progress, 7 open to eligible people

Autoimmune diseases happen when your immune system harms healthy parts of your body. UCSF is testing several treatments for these diseases, like using cord blood in pediatric cases and Belimumab for lung disease linked to connective tissues. Other trials include researching therapies for rheumatoid arthritis and generalized myasthenia gravis to assess their impact and safety.

Showing trials for

  • FT819 in B-cell Mediated Autoimmune Disease

    open to eligible people ages 12-70

    This is a phase 1 study designed to evaluate the safety, pharmacokinetics (PK), and anti-B-cell activity of FT819 following treatment with or without auxiliary medicinal product (AMP) in participants with moderate to severe active systemic lupus erythematosus (SLE), antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV), idiopathic inflammatory myositis (IIM), and systemic sclerosis (SSc). The study will consist of a dose-escalation stage, followed by an expansion stage to further evaluate the safety and activity of FT819.

    San Francisco, California and other locations

  • Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

    open to eligible people ages 18 years and up

    Interstitial lung disease (ILD) is a lung condition resulting in inflammation and stiffening of the lung, often associated with connective tissue diseases (CTDs). ILD causes reduction in lung volume, shortness of breath, cough and fatigue therefore has high impact on quality of life and is also the leading cause of death in participants with these conditions. The study will assess whether treatment of CTD-ILD participants with belimumab in addition to standard therapy will result in the stabilization and/or improvement of lung function and improve symptoms associated with ILD with an acceptable safety profile.

    San Francisco, California and other locations

  • RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis

    open to eligible people ages 18-70

    RESET-MG: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Participants with Generalized Myasthenia Gravis

    San Francisco, California and other locations

  • RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

    open to eligible people ages 6-75

    RESET-Myositis: Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects with Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

    San Francisco, California and other locations

  • Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

    open to eligible people ages 18-70

    This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dose levels will be given after the safety at lower dose levels is shown.

    San Francisco, California and other locations

  • IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

    open to eligible people ages 18-80

    The purpose of the study is to assess the efficacy, safety and tolerability of IMVT-1402 in adult participants with mild to severe generalized myasthenia gravis.

    San Francisco, California and other locations

  • Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

    open to all eligible people

    This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

    Oakland, California and other locations

  • Batoclimab in Participants With Active Thyroid Eye Disease

    Sorry, in progress, not accepting new patients

    To evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.

    San Francisco, California and other locations

  • Alopecia Areata Registry

    Sorry, in progress, not accepting new patients

    Alopecia areata is the loss of hair in patches that can proceed to loss of all hair (alopecia totalis or universalis). The purpose of the registry is to collect patient information and blood samples from people with alopecia areata.

    San Francisco, California and other locations

Our lead scientists for Autoimmune Disease research studies include .

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