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Caries clinical trials at UCSF

1 research study open to eligible people

Caries is a tooth decay caused by bacteria. UCSF is now recruiting participants for a clinical trial that tests a non-invasive way to find high carbohydrate intake and/or insulin resistance as risk factors for caries. Saliva insulin is the biomarker tested. Join the trial to help prevent tooth decay and improve dental health.

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  • Saliva Insulin as Biomarker of Risk Factors for Metabolic Dysregulation and Caries

    open to eligible people ages 5-10

    Saliva insulin shows promise as a non-invasive biomarker of high carbohydrate intake and/or insulin resistance, key risk factors for metabolic dysregulation and caries. Saliva insulin monitoring could potentially inform the planning and evaluation of interventions to prevent child obesity, diabetes and caries, without relying on self-reported measures from children, parents, child care providers or teachers. School-based public health screening programs, which have staff and data collection infrastructure in place to regularly and systematically collect saliva during oral health screening, have opportunity to monitor saliva insulin. This randomized controlled trial explores if saliva insulin is responsive to the kinds of obesity and caries intervention currently in progress in schools, namely drinking water intervention. Public health programs may justify adding saliva collection to protocol already in place if saliva insulin data are found to be actionable, i.e. sensitive to risk and intervention.

    San Francisco, California

Our lead scientists for Caries research studies include .

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