Checkpoint Kinase 2 Gene Mutation clinical trials at UCSF

1 research study open to eligible people

A checkpoint kinase 2 gene mutation is a change in a gene that can cause cancer. UCSF is researching drugs like Olaparib and ASTX727 to see if they help people with these mutations. These trials are testing the effectiveness and safety of the drugs.

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  • Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

    open to eligible people ages 18 years and up

    This is a single center, phase I/Ib clinical trial evaluating the combination of the poly adenosine diphosphate-ribose polymerase (PARP) inhibitor olaparib with the DNA methyltransferase (DNMT) inhibitor ASTX727, which is an oral formulation of decitabine with cedazuridine (a cytidine deaminase inhibitor that allows for oral administration). The study population consists of adults with advanced/metastatic solid tumor malignancies with germline or somatic mutations in the HRR pathway (i.e., BReast CAncer gene 1 (BRCA1), BReast CAncer gene 2(BRCA2), Partner And Localizer of BRCA2 (PALB2), ATM, and/or Checkpoint kinase 2 (CHEK2) mutations).

    San Francisco, California

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