Cognitive Decline clinical trials at UCSF

3 in progress, 2 open to eligible people

Showing trials for

  • Enhancing Attention and Wellbeing Using Digital Therapeutics

    open to eligible people ages 60-99

    The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovascular risk, and race/ethnicity). This knowledge gained from his high-impact study with transform the field of cognitive interventions, paving the way for a precision medicine model for cognitive enhancing interventions that improve quality of life for older adults and individuals with cognitive deficits at risk of developing dementia.

    San Francisco, California

  • Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

    open to eligible people ages 55-89

    Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to design and pilot-test an adaptive, randomized clinical trial (RCT) of cognitive training (CT) combinations aimed to enhance performance of instrumental activities of daily living (IADL) among persons with mild cognitive impairment (MCI). In the R01 phase, the objective is to identify the best combination of CT exercises to delay dementia onset among persons with MCI. The longitudinal endpoint goal is reducing incident dementia. The primary aim of the study is to determine which CT combination has the best probability to delay dementia by producing the largest IADL improvements. The study further aims to explore neuroimaging and novel blood-based biomarkers.

    San Francisco, California and other locations

  • Brain Health Together: A Live-Streaming Group-Based Digital Program

    Sorry, in progress, not accepting new patients

    The purpose of this study is to develop and test a comprehensive Brain Health Together program for older adults living with cognitive decline.

    San Francisco, California

Our lead scientists for Cognitive Decline research studies include .

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