End of Life clinical trials at UCSF

8 in progress, 5 open to eligible people

End of life care provides support for people nearing the end of life. UCSF is conducting trials on care planning for older homeless adults and comparing supportive care models for cancer patients. Other trials include introducing palliative care in liver disease treatment and evaluating psilocybin therapy in palliative care.

Showing trials for

  • Advance Care Planning With Formerly Homeless Older Adults Residing in Permanent Supportive Housing

    open to eligible people ages 50 years and up

    The homeless population is aging, with an increasing proportion of individuals over age 50 who experience accelerated aging, high rates of mortality, and a high risk of not having their wishes honored at the end of life. The goal of this randomized control trial (RCT) is to test the effectiveness of adapted evidence-based advance care planning (ACP) interventions for formerly chronically homeless older adults living in permanent supportive housing (PSH).

    San Francisco, California and other locations

  • Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

    open to eligible people ages 18 years and up

    This cluster-randomized comparative effectiveness trial compares a technology-based supportive cancer care (SCC) approach with a redesigned team-based supportive cancer care (SCC) approach.

    San Francisco, California and other locations

  • Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)

    open to eligible people ages 18-120

    This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-Hep (Functional Assessment of Cancer Therapy- Hepatobiliary). 14 Clinical Centers across US are recruited to participate in this study.

    Fresno, California and other locations

  • Pragmatic Trial of Psilocybin Therapy in Palliative Care

    open to eligible people ages 18 years and up

    This multicenter, triple-blind, phase 2, randomized controlled trial will evaluate the efficacy and safety of psilocybin therapy compared to an active control in treating demoralization in adults near the end of life (≤2 years life expectancy).

    San Francisco, California and other locations

  • PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

    open to eligible people ages 18-90

    There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70). Therefore, there are varied practice patterns around pursuing biopsy, resection, or palliation (best supportive care). This study aims to characterize the impact of palliative care versus biopsy versus resection on survival and quality of life in these patients. Also, it will aim to determine if there is a subset of patients that benefit the most from resection or biopsy, for which outcome, and how they could be identified preoperatively. This study is an international, multicenter, prospective, 3-arm cohort study of observational nature. Consecutive HGG patients will be treated with palliative care, biopsy, or resection at a 1:3:3 ratio. Primary endpoints are: 1) overall survival, and 2) quality of life at 6 weeks, 3 months and 6 months after initial presentation based on the EQ-5D, EORTC QLQ C30 and EORTC BN 20 questionnaires. Total duration of the study is 5 years. Patient inclusion is 4 years, follow-up is 1 year.

    San Francisco, California and other locations

  • Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

    Sorry, in progress, not accepting new patients

    This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer and their families.

    San Francisco, California and other locations

  • I CAN DO Surgical ACP

    Sorry, accepting new patients by invitation only

    The goal of the Advanced Care Planning (ACP) study is to encourage patients aged 65 or older who are referred for elective surgery to have advanced care planning.

    San Francisco, California and other locations

  • UC Health Care Planning Study

    Sorry, in progress, not accepting new patients

    Using a cluster randomized design at the clinic level, this project will implement and test three real-world, scalable advance care planning interventions among primary care clinics across three University of California health systems. Seriously ill patients identified using data from the electronic health record will receive (1) an advance directive with targeted messaging, (2) intervention 1 plus prompting to engage with the Prepare For Your Care website, or (3) intervention 2 plus engagement from a clinic-based facilitator. A Research cohort of patients will provide complete surveys at baseline, 12 and 24 months. The main outcomes are advance directive completion among the population cohort and goal concordant care among the Research cohort at 12 months.

    San Francisco, California and other locations

Our lead scientists for End of Life research studies include .

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