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Epilepsy clinical trials at UCSF
5 in progress, 1 open to new patients

  • The Human Epilepsy Project

    open to eligible people ages 12–60

    HEP is a five-year, prospective, observational study whose primary goal is to identify clinical characteristics and biomarkers predictive of disease outcome, progression, and treatment response in participants with newly treated focal epilepsy.

    San Francisco, California and other locations

  • Stereotactic Laser Ablation for Temporal Lobe Epilepsy

    Sorry, currently not accepting new patients, but might later

    The study is designed to evaluate the safety and efficacy of the Visualase MRI-guided laser ablation system for mesial temporal epilepsy (MTLE).

    San Francisco, California and other locations

  • Radiosurgery or Open Surgery for Epilepsy Trial

    Sorry, in progress, not accepting new patients

    This study will compare radiosurgery (focused radiation, Gamma Knife Radiosurgery) with temporal lobectomy (standard surgical care) as a treatment of temporal lobe epilepsy. Patients who have seizures that begin in their temporal lobe that are not controlled with medications into the trial will be offered entry. Patients with a high likelihood of having their seizures controlled with open surgery will have treatment randomized between the standard surgery and radiosurgery. A prior study has shown that focused radiation (radiosurgery) may also reduce or eliminate seizures arising from the temporal lobe. The main study hypothesis is that radiosurgery is as safe and effective as temporal lobectomy in treating patients with seizures arising from the medial temporal lobe.

    San Francisco, California and other locations

  • RNS® System Epilepsy PAS

    Sorry, accepting new patients by invitation only

    The purpose of the study is to follow patients with partial onset seizures prospectively over 5 years in the real-world environment to gather data on the long-term safety and effectiveness of the RNS System at qualified CECs by qualified neurologists, epileptologists, and neurosurgeons trained on the RNS System.

    San Francisco, California and other locations

  • SANTE - Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy

    Sorry, in progress, not accepting new patients

    The purpose of this research is to study the safety and effectiveness of bilateral stimulation of the anterior nucleus of the thalamus as adjunctive therapy for reducing the frequency of seizures in adults diagnosed with epilepsy characterized by partial-onset seizures, with or without secondary generalization, that are refractory to antiepileptic medications.