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FGFR2 Gene Activation clinical trials at UCSF

1 research study open to eligible people

FGFR2 Gene Activation is a study on a gene that can be responsible for some types of cancer. UCSF is doing a clinical trial called "REFOCUS" to test a new drug that targets this gene. The trial is for patients with advanced solid tumors and will test the safety and effectiveness of the drug.

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  • REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors

    open to eligible people ages 18 years and up

    This is a Phase 1/2, open-label, FIH study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDy), and antineoplastic activity of RLY-4008, a potent and highly selective FGFR2 inhibitor, in patients with unresectable or metastatic cholangiocarcinoma (CCA) and other solid tumors. The study consists of 3 parts: a dose escalation (Part 1), a dose expansion (Part 2), and an extension (Part 3).

    San Francisco, California and other locations

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