Gynecologic Cancer clinical trials at UCSF

4 in progress, 3 open to eligible people

Gynecologic cancer is cancer of the female reproductive organs. At UCSF, one study looks at why patients feel tired during cancer treatments. Another study tests a new drug for advanced tumors. UCSF is also researching how frailty impacts recovery in gynecologic cancer patients.

Showing trials for

  • First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

    open to eligible people ages 18 years and up

    Study STX-478-101 is a multipart, open-label, phase 1/2 study evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of STX-478 in participants with advanced solid tumors with P13Ka mutations. Part 1 will evaluate STX-478 as monotherapy in participants with advanced solid tumors. Part 2 will evaluate STX-478 therapy as combination therapy with fulvestrant in participants with hormone receptor positive (HR+) breast cancer. Part 3 will evaluate STX-478 as combination therapy with fulvestrant and a CDK4/6 Inhibitor (either Ribociclib or Palbociclib) in participants with HR+ breast cancer. Each study part will include a 28-day screening period, followed by treatment with STX-478 monotherapy or combination therapy.

    San Francisco, California and other locations

  • Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT

    open to eligible people ages 18 years and up

    Cancer-related fatigue (CRF) is a significant problem for cancer patients. This prospective, basic science, observational study will evaluate for changes in CRF associated with molecular characteristics prior to, during, and at the completion of non-investigational, standard-of-care, combined chemotherapy and radiation therapy (CCRT) and to develop and assess predictive models for CRF severity.

    San Francisco, California

  • PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

    open to eligible females ages 18 years and up

    This study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients with gynecologic cancer.

    San Francisco, California and other locations

  • Exercise and Movement to Enhance Resiliency in Cancer Patients

    Sorry, not yet accepting patients

    This is a single-center, pilot, hybrid type 1 design implementation study to evaluate the feasibility and implementation of a personalized digital exercise program and a virtual support group to improve patient-centered outcomes in patients receiving treatment for gynecologic cancer receiving treatment at University of California, San Francisco.

    San Francisco, California

Our lead scientists for Gynecologic Cancer research studies include .

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