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Hypoplastic Left Heart Syndrome clinical trials at UCSF

2 in progress, 1 open to eligible people

Showing trials for
  • Effect of Fetal Aortic Valvuloplasty on Outcomes

    open to all eligible people

    In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects. The underdevelopment can occur gradually during fetal growth caused by a narrowing of the aortic valve. At some international centers, such fetuses are treated with a balloon dilation of the narrowed valve, but there is no scientifically sound evidence that this treatment is effective. The aim of this study is: 1/ to evaluate whether balloon dilation during the fetal period of a narrowed aortic valve can reduce the risk of the left ventricle becoming underdeveloped and the baby being born with a so-called univentricular heart (HLHS); 2/ to investigate whether such treatment improves the prognosis for this group of children with a very complex and severe heart defect and 3/ to also describe side effects and risks in fetuses and mothers of the fetal procedure.

    San Francisco, California and other locations

  • Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome

    Sorry, in progress, not accepting new patients

    For fetuses with severe aortic stenosis, in utero balloon aortic valvuloplasty may improve fetal growth of left heart structures and thus improve potential for biventricular repair strategies after birth.

    San Francisco, California

Our lead scientists for Hypoplastic Left Heart Syndrome research studies include .

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