Knee Replacement clinical trials at UCSF
2 research studies open to eligible people
Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial
open to eligible people ages 18 years and up
The Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty (TKA): Multi-Center Trial is a study that will compare the effectiveness of various perioperative strategies for antibiotic delivery as prophylaxis for periprosthetic joint infections (PJI) and surgical site infection in elective primary TKA. The investigators hypothesize that a single dose of prophylactic antibiotic administered within 60 minutes before the incision is not an effective way to prevent PJI in elective primary total knee arthroplasty (TKA). The investigators also hypothesize that the prolonged delivery (24 hours) of antibiotic prophylaxis after surgery does not further reduce the incidence of PJI in elective primary TKA. Duke University is the only site recruiting both primary total knee arthroplasty and unilateral knee arthroplasty.
San Francisco, California and other locations
Dexamethasone in Total Knee Arthroplasty
open to eligible people ages 18 years and up
The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
San Francisco, California and other locations
Our lead scientists for Knee Replacement research studies include Thomas Vail.
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