KRAS Activating Mutation clinical trials at UCSF
2 in progress, 1 open to eligible people
KRAS activating mutation is a genetic alteration that may contribute to cancer growth. At UCSF, scientists are evaluating how effective and safe certain drug combinations are for treating pancreatic cancer. These trials help to advance our understanding of potential cancer therapies.
Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
open to eligible people ages 18 years and up
This study will assess the safety and efficacy of avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxel in patients with Pancreatic Ductal Adenocarcinoma (PDAC) who have been previously untreated.
San Francisco, California and other locations
Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Sorry, in progress, not accepting new patients
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
San Francisco, California and other locations
Our lead scientists for KRAS Activating Mutation research studies include Andrew Ko.
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