Lennox-Gastaut Syndrome clinical trials at UCSF

3 in progress, 2 open to eligible people

Lennox-Gastaut syndrome is a rare epilepsy that leads to frequent seizures and developmental problems. UCSF is investigating soticlestat to find out if it can lessen seizures when added to other treatments. UCSF is also testing a brain-responsive device to see if it reduces seizure frequency safely.

Showing trials for

  • Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome

    open to eligible people ages 2-56

    The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of seizures in children and adults with Dravet Syndrome (DS) or Lennox-Gastaut Syndrome (LGS). Participants will receive their standard anti-seizure therapy, plus tablets of soticlestat. There will be scheduled visits and follow-up phone calls throughout the study.

    San Francisco, California and other locations

  • RNS System LGS Feasibility Study

    open to eligible people ages 12 years and up

    To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or older with Lennox Gastaut Syndrome (LGS) who are refractory to antiseizure medications. The intent is to determine the feasibility and the optimal design of a subsequent pivotal study in order to expand the indication for use for the RNS System as a treatment for patients with medically intractable LGS.

    San Francisco, California and other locations

  • LP352 in Subjects With Developmental and Epileptic Encephalopathy

    Sorry, in progress, not accepting new patients

    The objective of this study is to assess the long-term safety, tolerability, and efficacy of adjunctive therapy of LP352 in subjects with developmental and epileptic encephalopathies who completed participation in Study LP352-201.

    San Francisco, California and other locations

Our lead scientists for Lennox-Gastaut Syndrome research studies include .

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