Mitral Valve Disease clinical trials at UCSF

2 in progress, 1 open to eligible people

Mitral valve disease is a problem with the valve between the heart's left chambers. UCSF is studying a new device to fix this valve without surgery. This trial checks if the device is safe and works well.

Showing trials for

  • Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

    open to eligible people ages 18 years and up

    To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)

    San Francisco, California and other locations

  • Melody Valve in the Mitral and Tricuspid Position

    Sorry, in progress, not accepting new patients

    The Melody valve has historically been used for pulmonary valve replacements; however it has been more recently used in the mitral and tricuspid positions. This multi-center, retrospective, observational study will review the durability of the Melody valve inserted into the mitral or tricuspid positions. Patients who have undergone Melody valve insertion into either the mitral or tricuspid positions prior to December, 2014 will be eligible for the study. Basic de-identified patient demographics will be collected as well as select clinical data. Ventricular function and valvar function of the affected valve will be retrospectively reviewed both prior to surgery and following, as well as review of operative data. The investigators will also review the most recent follow up data and any subsequent re-interventions on the Melody valve. Data from all sites will be entered into an external REDCap database, using only de-identified data.

Our lead scientists for Mitral Valve Disease research studies include .

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