Mitral Valve Insufficiency clinical trials at UCSF
5 in progress, 4 open to eligible people
Mitral valve insufficiency occurs when the mitral valve fails to seal properly, leading to blood leakage. UCSF is running a trial to examine the safety of the Edwards PASCAL system for valve repair. Another trial compares the MitraClip device with surgical options. Additionally, UCSF studies treatments for older adults with this condition.
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
open to eligible people ages 18 years and up
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
San Francisco, California and other locations
MitraClip REPAIR MR Study
open to eligible people ages 18 years and up
The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team.
San Francisco, California and other locations
Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)
open to eligible people ages 65 years and up
This is a prospective, multicenter, open-label, randomized trial comparing mitral valve (MV) transcatheter edge-to-edge repair (TEER) to surgical repair (1:1 ratio) in patients with primary, degenerative mitral regurgitation (MR). The trial will be conducted in the U.S., Canada, Germany and the United Kingdom, and is designed as a strategy trial. Thus, all devices legally marketed for TEER of primary degenerative MR in a particular country are eligible to be used in this trial.
San Francisco, California and other locations
EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
open to eligible people ages 18 years and up
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
San Francisco, California and other locations
Beating Heart Mitral Valve Repair With the HARPOON™ System
Sorry, in progress, not accepting new patients
The objective of the study is to evaluate the safety and effectiveness of the HARPOON™ System in the treatment of patients with severe degenerative mitral regurgitation (DMR).
San Francisco, California and other locations
Our lead scientists for Mitral Valve Insufficiency research studies include Richard Cheng, MD Sammy Elmariah, MD.
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