Neuropathic Pain clinical trials at UCSF
2 in progress, 1 open to eligible people
open to eligible people ages 18-75
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery. Traditional pain management strategies reply on pain medication such as opioids for pain control. However, these drugs do not work well for pain associated with movement or the the nerve pain (tingling, electrical sensations) after surgery. In addition, opioids are associated with significant side effects such as nausea, vomiting, respiratory depression, depression, cognitive dysfunction and risk of persistent opioid use. Neuropathic pain medications, such as venlafaxine are effective in managing nerve pain. Recent studies also support its potential role in acute pain management. Here, we propose a prospective randomized clinical trial 1) to evaluate the efficacy of Venlafaxine in reducing pain intensity and opioid consumption at post-operative day 1 (POD1) and 1- week after surgery, and 2) to examine whether the use of Venlafaxine will reduce the incidents of chronic postsurgical pain in TKA patients at 3-month time point.
San Francisco, California
Sorry, accepting new patients by invitation only
This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.
San Francisco, California and other locations
Our lead scientists for Neuropathic Pain research studies include Matthias Behrends, MD.