Pupillary Miosis clinical trials at UCSF

1 research study open to eligible people

Pupillary miosis happens when pupils become smaller. UCSF is researching the effect of opioids on pupil size in people aged 40 to 60. The trials measure how opioids impact pupil changes.

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  • Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

    open to eligible people ages 40-60

    This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old. Population data indicate that pupil size and PUAL decline slightly with age. The investigators will explore whether PUAL proves to be a sensitive indicator of opioid exposure and respiratory depression in this older group.

    San Francisco, California

Our lead scientists for Pupillary Miosis research studies include .

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