Kidney Stones clinical trials at UCSF
5 in progress, 1 open to eligible people
Kidney stones are hard deposits made of minerals and salts that form inside the kidneys. UCSF is testing a new system called Break Wave™ to treat stones in the upper urinary tract. This trial explores how well the system works in breaking up these stones.
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
open to eligible people ages 18 years and up
The goal of this clinical trial is to test the Break Wave™ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones. Participants will a) undergo the Break Wave™ procedure, b) have a telehealth visit at 2 weeks, and c) return for an imaging study at approximately 10 weeks post-procedure.
San Francisco, California and other locations
Ambulatory Versus Inpatient Percutaneous Nephrolithotomy
Sorry, in progress, not accepting new patients
The goal of the study is to determine if ambulatory tubeless PCNL is safe and effective compared to inpatient PCNL with a nephrostomy tube.
San Francisco, California
Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study
Sorry, in progress, not accepting new patients
This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology. Up to 30 subjects will be included. The procedure will be performed in a hospital surgical environment as an outpatient (without being admitted) or in a non-surgical environment such as a clinic or office procedure room. The procedure will be performed under varying levels of anesthesia ranging from no anesthesia to general anesthesia (fully asleep). Stones will be limited to ≤ 10 mm for lower pole stones and ≤ 20 mm everywhere else. Safety will be measured by the self-reported occurrences of adverse events, unplanned emergency department or clinic visits, and the need for further intervention. Fragmentation will be measured by self-reported stone passage and a comparison of computed tomography (CT) images before and after the procedure.
San Francisco, California and other locations
Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy
Sorry, not yet accepting patients
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in patients with moderate to high risk of infection undergoing ureteroscopy. The main questions it aims to answer are: 1. Determine the safety and efficacy of a short course (2 days) as compared to a long course (7 days) 2. Identify secondary predictors of post-operative infectious complications
San Francisco, California
Video Home Visits for Dietary Counselling
Sorry, not yet accepting patients
This pilot study aims to develop a protocol for home video informed dietary counseling with the goal of reducing overall sodium consumption among kidney stone formers. To accomplish this the investigators will: 1)Assess which data available on video visits are most informative to convey patient sodium consumption, and 2) Administer virtual home visits with informed dietary counseling in our intervention arm and compare this to standard dietary counseling looking specifically at the outcome of 24-hour urine sodium excretion results over time. This study will benefit dramatically from the rapid growth of telehealth medical visits as a consequence of the SARS-CoV-2 pandemic, with the ultimate goal to improve and adapt patient dietary counseling for the prevention of kidney stone disease in the new and evolving era of telehealth.
Our lead scientists for Kidney Stones research studies include David Bayne Justin Ahn, MD.
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