Surgical Wound Infection clinical trials at UCSF
3 research studies open to eligible people
Surgical wound infections are caused by bacteria entering a surgical cut. UCSF is conducting trials to prevent these infections by testing skin cleaning methods and antibiotic powders for high-risk fractures. They are also comparing antibiotic treatments for severe open fractures to find the best approach.
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
open to eligible people ages 18 years and up
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
San Francisco, California and other locations
New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
open to eligible people ages 18-64
The proposed study is a multi-center, prospective randomized controlled trial comparing current standard of care treatment to the SEXTANT treatment protocol in patients with Type III open fractures of the tibia and IIIB fractures of the ankle and hindfoot.
San Francisco, California and other locations
Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures At High Risk of Infection: TOBRA
open to eligible people ages 18-80
The overall objective is to compare the effect of Vancomycin and Tobramycin powder combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation infections of tibial plateau and tibial pilon fractures at high risk of infection (collectively considered the "study injuries").
San Francisco, California and other locations
Our lead scientists for Surgical Wound Infection research studies include Saam Morshed, MD Deborah Yokoe, MD, MPH.
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