Not currently recruiting at UCSF

Mediators of Atherosclerosis in South Asians Living in America

a study on Atherosclerosis Peripheral Artery Disease Cardiovascular Disease Heart Disease Coronary Artery Disease

Summary

Eligibility
for people ages 40-84 (full criteria)
Location
at San Francisco 5391959, California 5332921 and other locations
Dates
study started
study ends around
Principal Investigator
by Alka Kanaya, MD
Headshot of Alka Kanaya
Alka Kanaya

Description

Summary

South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.

Keywords

Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease, Coronary Disease

Eligibility

You can join if…

Open to people ages 40-84

  • South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
  • age between 40 and 84 years.

You CAN'T join if...

  • Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
  • Current atrial fibrillation
  • Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
  • Active treatment for cancer
  • Life expectancy less than 5 years due to serious medical illness
  • Impaired cognitive ability as judged by the reviewer
  • Plans to move out of the study region in next 5 years
  • Weight greater than 300 pounds
  • Living in a nursing home or on a waiting list
  • Unable to speak/read/write English, Hindi, Urdu, or Bangla

Locations

  • UCSF in progress, not accepting new patients
    San Francisco 5391959 California 5332921 94115 United States
  • New York University accepting new patients
    New York 5128581 New York 5128638 United States
  • Northwestern University accepting new patients
    Chicago 4887398 Illinois 4896861 60611 United States

Lead Scientist at UCSF

  • Alka Kanaya, MD
    I have focused my clinical research in the field of type 2 diabetes and obesity and have developed a three-pronged research program that is unified under this theme. The first arm consists of using existing cohort studies to test novel biomarkers that predict diabetes and cardiovascular disease. The second arm is to create a South Asian cohort to study these risk factors in a very high risk group.

Details

Status
accepting new patients at some sites,
but this study is not currently recruiting here
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT01207167
Study Type
Observational
Participants
Expecting 2314 study participants
Last Updated