Chronic Obstructive Pulmonary Disease clinical trials at UCSF
8 in progress, 4 open to eligible people
Chronic obstructive pulmonary disease (COPD) causes breathing difficulties. UCSF is exploring a new inhaled drug for COPD patients with lung high blood pressure. They are also studying exercise programs for patients in under-resourced areas. UCSF is observing young adults to better understand how COPD starts and progresses.
Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
open to eligible people ages 40-85
Researchers are looking for ways to treat pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD). The goal of the study is to learn if people who take frespaciguat can walk farther in 6 minutes at Week 24 compared to…
San Francisco, California and other locations
Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD
open to eligible people ages 40-90
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities. While few interventions effectively modify the course of COPD and improve outcomes, pulmonary…
San Francisco, California and other locations
Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
open to eligible people ages 18-85
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary…
San Francisco, California
SPIROMICS Study of Early COPD Progression (SOURCE)
open to eligible people ages 30-55
This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals. The study has three main goals: - To use CT scan imaging to identify which…
San Francisco, California and other locations
Pulmonary Specialist-Health Coach Consult Model Study
Sorry, in progress, not accepting new patients
The Pulmonary Specialist-Health Coach Consultation (PuSHCon) study examines the implementation of health coach-assisted consultations to improve access to specialist care and implementation of specialist recommendations for patients with COPD,…
San Francisco, California and other locations
SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)
Sorry, in progress, not accepting new patients
Primary Objective: Primary population (former smokers cohort): - Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary …
Fresno, California and other locations
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
Sorry, accepting new patients by invitation only
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as retrospective standard of care…
San Francisco, California and other locations
COPD Subgroups and Biomarkers
Sorry, in progress, not accepting new patients
SPIROMICS I and SPIROMICS II are observational studies of Chronic Obstructive Pulmonary Disease (COPD). SPIROMICS I had two main aims: (1) To find groups of patients with COPD who share certain characteristics; (2) To find new ways of measuring…
San Francisco, California and other locations
Our lead scientists for Chronic Obstructive Pulmonary Disease research studies include Rachel Willard-Grace, MPH John Fahy, MD, MS Neeta Thakur Prescott G. Woodruff, MD, MPH.
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