Nicotine clinical trials at UCSF

5 in progress, 2 open to eligible people

Nicotine is a drug found in tobacco that affects the nervous system. UCSF is conducting studies on how different kinds of nicotine, including synthetic, are absorbed and act in the body. These trials are important for understanding the health impacts of electronic cigarettes.

Showing trials for

  • Pharmacodynamics of Synthetic Nicotine

    open to eligible people ages 21-65

    In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

    San Francisco, California

  • Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

    open to eligible people ages 21-70

    This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.

    San Francisco, California

  • Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke

    Sorry, currently not accepting new patients, but might later

    This study compares the health effects of dermal and inhalational exposure to thirdhand cigarette smoke to those of inhalational exposure to secondhand cigarette smoke in healthy, adult nonsmokers. Our hypothesis is that dermal exposure increases exposure to the tobacco specific carcinogen, NNK and may affect both endothelial function and epidermal integrity.

    San Francisco, California

  • Melanin and Dermal Uptake of Thirdhand Cigarette Smoke

    Sorry, not yet accepting patients

    This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.

    San Francisco, California

  • Clinical Pharmacology of Marijuana-Tobacco Co-administration

    Sorry, not yet accepting patients

    This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.

    San Francisco, California

Our lead scientists for Nicotine research studies include .

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