Nicotine clinical trials at UCSF
7 in progress, 5 open to eligible people
Clinical Pharmacology of Marijuana-Tobacco Co-administration
open to eligible people ages 21-65
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.
San Francisco, California
Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
open to eligible people ages 18 years and up
This study is investigating tobacco use and providing tobacco treatment among people experiencing homelessness in California, in San Francisco and Los Angeles.
San Francisco, California
Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
open to eligible people ages 18-50
This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.
San Francisco, California
Pharmacodynamics of Synthetic Nicotine
open to eligible people ages 21-65
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
San Francisco, California
Social Media Support Groups for Adolescent Vaping Cessation
open to eligible people ages 13 years and up
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
San Francisco, California
Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke
Sorry, currently not accepting new patients, but might later
This study compares the health effects of dermal and inhalational exposure to thirdhand cigarette smoke to those of inhalational exposure to secondhand cigarette smoke in healthy, adult nonsmokers. Our hypothesis is that dermal exposure increases exposure to the tobacco specific carcinogen, NNK and may affect both endothelial function and epidermal integrity.
San Francisco, California
Understanding Oral Nicotine Pouch Use in Healthy Volunteers
Sorry, not yet accepting patients
The goal of this clinical trial is to understand how using oral nicotine pouches effects the body in healthy volunteers. The main questions it aims to answer are: 1. With multiple use of oral nicotine pouches (ONPs) throughout the day, participants will adjust their intake of nicotine to be similar to or higher than that seen with cigarette smoking or vaping. 2. With multiple use of ONPs throughout the day, participants will experience satisfaction, psychological reward and relief of withdrawal symptoms similar to that seen with cigarette smoking or vaping. Participants will rate ONP use as a satisfactory substitute for cigarette smoking or vaping. 3. Examine the cardiovascular effects (blood pressure and heart rate) of placebo, 3mg and 6mg ONPs, and the participants' usual cigarette or e-cigarette (vape). Participants will: - use 3 different strengths of ONPs (0 mg, 3 mg, 6 mg) and their usual inhaled nicotine product (cigarette or e-cigarette/vape) - visit the hospital research ward on 4 separate days for 8 hours each day - use one of each of the products in a randomized order (by chance, like flipping a coin) on each of the 4 hospital study days
San Francisco, California
Our lead scientists for Nicotine research studies include Pamela M Ling, MD, MPH Suzaynn F Schick, PhD Neal Benowitz Maya Vijayaraghavan, MD Gideon St Helen.
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