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for people ages 40 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion:



A randomized, parallel, placebo controlled trial to evaluate the effect of 100mg/day losartan on the progression of emphysema as measured by quantitative HRCT compared to placebo


This is a pragmatic trial designed to test if a treatment, losartan, may decrease the progression of Chronic Obstructive Pulmonary Disease (COPD). Losartan is an angiotensin receptor blocking agent, commonly used as an antihypertensive agent, which has been shown to alter cardiac remodeling after myocardial infarction and renovascular remodeling in diabetes-mellitus. In this trial participants with mild to severe COPD, with Computed Tomography (CT) evidence of emphysema (5-35% of voxels with < -950 Hounsfield Units), will be randomly assigned to receive 100mg/day of losartan or placebo for 48 weeks. The primary outcome measure will be the rate of progression of emphysema, quantified as the percent of lung voxels with a density less than -950 HU as measured by High Resolution CT (HRCT, from baseline to 48 weeks.


Emphysema COPD HRCT losartan Pulmonary Emphysema


You can join if…

Open to people ages 40 years and up

  • Mild to severe COPD: Ratio of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than or equal to 0.70, FEV1 30-70% of predicted
  • Current or former smoker
  • HRCT scan with 5-35% of voxels with density less than -950 Hounsfield Units (HU)
  • Ability to understand and willingness to sign consent documents

You CAN'T join if...

  • Current therapy with angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)
  • Known intolerance to ACE inhibitor or ARB
  • History of angioedema
  • Conventional indication for ACE inhibitor or ARB (e.g., history of myocardial infarction, known cardiomyopathy)
  • Renal insufficiency (GFR <30 mL/min by Cockcroft-Gault calculation)
  • Current regular use of NSAIDs defined as daily use 5 or more days of the week for more than one month
  • Potassium supplementation or serum potassium level of 5.0 milliequivalents (mEq)/dL or higher at V1
  • Current use of a potassium sparing diuretic
  • COPD exacerbation requiring treatment within 6 weeks at V1
  • Chronic systemic corticosteroid use of more than 10mg/day of prednisone
  • Chronic oxygen use at more than 2 L/min nasal cannula at rest or clinical evidence of cor pulmonale
  • Untreated arterial hypertension (systolic blood pressure greater than140 mm Hg,diastolic blood pressure greater than 90 mm Hg)
  • Blood pressure less than 90 mm Hg systolic or 60 mm Hg diastolic while standing or sitting
  • Known unilateral or bilateral renal artery stenosis higher than 70%
  • Previous lung resection surgery
  • Evidence of interstitial, occupational or chronic infectious lung disease
  • Changes to chest that preclude adequate HRCT imaging (e.g. Metallic objects in the chest such as shrapnel or pacemaker leads)
  • For women of child bearing potential, positive pregnancy test or unwillingness to use two methods of birth control or abstinence for the duration of the study
  • Major chronic illnesses which in the judgment of the study physician would interfere with participation in the study e.g. including but not limited to: cardiac, renal,hepatic (LFTs more than 2.5x normal upper limit), neurological, psychiatric, endocrine or neoplastic diseases, uncontrolled diabetes, uncontrolled HIV infection or other immune system disorder, hyperthyroidism, seizure disorders, non-skin cancer, rheumatic diseases
  • Failure to keep screening appointments or other indicators of non-adherence
  • Inability to be contacted by telephone
  • Intention to leave area within 12 months


  • University of California at San Francisco accepting new patients
    San Francisco, California, 94143, United States
  • University of California at San Diego accepting new patients
    San Diego, California, 92103, United States
  • University of Arizona accepting new patients
    Tucson, Arizona, 85724, United States
  • Pacific Northwest Airways - VA Puget Sound Healthcare System accepting new patients
    Seattle, Washington, 98108, United States
  • National Jewish Medical and Research Center accepting new patients
    Denver, Colorado, 80206, United States
  • Baylor College of Medicine accepting new patients
    Houston, Texas, 77030, United States
  • St. Louis Asthma Clinical Research Center - Washington University School of Medicine accepting new patients
    Saint Louis, Missouri, 63110, United States
  • Illinois Consortium accepting new patients
    Chicago, Illinois, 60611, United States
  • St. Vincent Hospital and Health Care Center, Inc. accepting new patients
    Indianapolis, Indiana, 46260, United States
  • University of Alabama at Birmingham accepting new patients
    Birmingham, Alabama, 35249, United States
  • University of Michigan accepting new patients
    Ann Arbor, Michigan, 48109-5360, United States
  • University of Florida College of Medicine accepting new patients
    Jacksonville, Florida, 32209, United States
  • University of South Florida accepting new patients
    Tampa, Florida, 33613, United States
  • Duke University Medical Center accepting new patients
    Durham, North Carolina, 27710, United States
  • Temple University accepting new patients
    Philadelphia, Pennsylvania, 19140, United States
  • Columbia University Medical Center accepting new patients
    New York, New York, 10032, United States
  • Vermont Lung Center at The University of Vermont accepting new patients
    Colchester, Vermont, 05466, United States


accepting new patients
Start Date
Completion Date
Johns Hopkins University
Phase 4
Lead Scientist
Stephen Lazarus
Study Type
Last Updated
November 22, 2017
I’m interested in this study!