Single Cell Genomics of Psoriatic Skin

a study on Psoriasis

Summary

for people ages 18 years and up (full criteria)
healthy people welcome
at San Francisco, California
study started
estimated completion
Wilson Liao, MD

Description

Summary

The purpose of this study is to understand how genetics play a role in psoriasis. Specifically, a genetic allele HLA-Cw6 is known to be associated with psoriasis, and this study aims to find out how it affects genetic and protein expression in patients with psoriasis, compared to healthy people, at a single-cell level using a novel flow cytometry and RNA-sequencing protocol.

Official Title

Elucidating the Fundamental Differences Between HLA-Cw6 Positive and HLA-Cw6 Negative Psoriasis Skin Lesions, With a Comparison to Healthy Skin, at the Single Cell Level of the Infiltrated Immune Cell Types

Keywords

Psoriasis immunology, genetics Skin biopsy Blood draw

Eligibility

You can join if…

Open to people ages 18 years and up

For subjects in the psoriasis group:

  1. Ability to provide written consent and comply with the protocol
  2. At least 18 years of age
  3. Diagnosis of plaque psoriasis for at least 6 months prior to enrollment
  4. BSA > 5% and at least one target plaque on trunk or extremities greater than 10cm2

For control subjects:

  1. Ability to provide written consent and comply with the protocol
  2. At least 18 years of age
  3. No previous diagnosis of psoriasis or other inflammatory skin conditions

You CAN'T join if...

For subjects in the psoriasis group:

  1. Subject has non-plaque form of psoriasis.
  2. Subject has drug-induced psoriasis.
  3. Pregnancy at any point during the study period.
  4. Known allergy to lidocaine, other local anesthetics, or any component of local anesthetic agents.
  5. Known HIV positive status.
  6. Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
  7. Known coagulopathy.

For control subjects:

  1. Any physical examination findings by the investigators consistent with psoriasis or other inflammatory skin conditions.
  2. Pregnancy at any point during the study period.
  3. Known allergy to lidocaine, other local anesthetics, or any component of local anesthetic agents.
  4. Known HIV positive status.
  5. Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
  6. Known coagulopathy.
  7. Use of any immunosuppressant or immunomodulating therapies within 6 months.

Location

  • UCSF Psoriasis Center accepting new patients
    San Francisco California 94118 United States

Lead Scientist

  • Wilson Liao, MD
    ACADEMIC INTERESTS Dr. Liao serves as Director of the UCSF Psoriasis and Skin Treatment Center and is deeply engaged in patient care, clinical trials, and basic science research. The Liao laboratory studies the genetics and environmental triggers of psoriasis, a common immune-mediated skin disease.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT02929745
Study Type
Interventional
Last Updated