for people ages 40-80 (full criteria)
Healthy Volunteers
healthy people welcome
at San Francisco, California and other locations
study started
completion around
Principal Investigator
by Adam L Boxer, MD, PhD
Headshot of Adam L Boxer
Adam L Boxer



The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug trials. The study will also provide information about the relative value of novel imaging techniques for diagnosis, as well as the value of imaging techniques versus testing of blood, urine, and cerebrospinal fluid (CSF) 'biomarkers'.

Official Title

The Four-Repeat Tauopathy Neuroimaging Initiative


Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP), CBD, CBS, CBGD, PSP, nfvPPA, oPSP, vPSP, o/vPSP, Corticobasal Degeneration, Corticobasal Syndrome, Cortocal-basal Ganglionic Degeneration, Progressive Supranuclear Palsy, Nonfluent Variant Primary Progressive Aphasia, Oligosymptomatic Progressive Supranuclear Palsy, Variant Progressive Supranuclear Palsy, Biomarker, Neuroimaging, MRI, PET, Tau, Oculomotor, Retinal Imaging, Paralysis, Aphasia, Primary Progressive Aphasia, Pick Disease of the Brain, Frontotemporal Dementia, Tauopathies, PSP & CBD


You can join if…

Open to people ages 40-80

  • No known history of neurological disease, or meet criteria for one of the following: Corticobasal Syndrome or Degeneration (CBS or CBD); Progressive Supranuclear Palsy (PSP); or Oligo- or Variant- Progressive Supranuclear Palsy (o/vPSP)
  • Needs a reliable study partner who has frequent contact with the participant, who is available to provide information about the participant, and who can accompany the participant to research visits as needed
  • Must be willing and able to undergo testing procedures, which include longitudinal follow-up visits
  • Must be able to walk five steps with minimal assistance

You CAN'T join if...

  • Significant neurological disease other than CBD, PSP, or a variant PSP syndrome.
  • Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, or metal fragments or metal objects in the eyes, skin, or body
  • In the site investigator's opinion, inability to complete sufficient key study procedures, or some other equivalent assessment of impairment


    San Francisco California 94158 United States
  • University of California, San Diego (UCSD)
    San Diego California 92037 United States

Lead Scientist at UCSF

  • Adam L Boxer, MD, PhD
    Adam L. Boxer, MD, PhD is the Endowed Professor in Memory and Aging in the Department of Neurology, Weill Institute of Neuroscience, University of California, San Francisco (UCSF). He received his MD and PhD from the New York University Medical Center Medical Scientist Training Program, completed a Neurology Residency at Stanford and a Neurobehavior Fellowship at UCSF.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 232 study participants
Last Updated