for people ages 18 years and up (full criteria)
healthy people welcome
at San Francisco, California
study started
estimated completion
Robert Kersten



The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.

Official Title

The Role of Topical Antibiotic Prophylaxis in Eyelid Surgery


The use of prophylactic topical antibiotic therapy after eyelid surgery is widespread. Due to increasing antibiotic resistance, antibiotic-related complications, and healthcare costs, the investigators wish to determine whether prophylactic post-operative antibiotic ointment is truly necessary. After all, existing dermatology literature currently recommends against the routine use of antibiotic ointment after various surgical procedures (e.g. Mohs surgery). The investigators aim to perform a prospective randomized control trial at the University of California, San Francisco. The investigators aim to recruit a total of 400 oculoplastics patients undergoing eyelid surgery or surgery involving peri-orbital incisions from 2017 through 2019.


Antibiotic Side Effect Eyelid; Wound Eyelid Diseases Surgical Wound Infection Surgical Wound, Recent Surgical Incision Skin Cancer Face Antibiotic Allergy Surgical Site Infection Infection Communicable Diseases Wound Infection Skin Neoplasms Surgical Wound Wounds and Injuries Anti-Bacterial Agents Erythromycin Erythromycin Estolate Erythromycin Ethylsuccinate Erythromycin stearate Bacitracin Antibiotics, Antitubercular Anti-Infective Agents, Local Lubricant Eye Drops Anti-Infective Agents Topical Anti-Infective Product Topical Ointment Topical Antibiotic Ointment Topical Artificial Tear Ointment


You can join if…

Open to people ages 18 years and up

Patients aged 18 and older who are undergoing various eyelid procedures in an office, ambulatory care center, or operating room including but not limited to:

  • blepharoplasty (upper and lower lids);
  • ectropion repair;
  • entropion repair;
  • external dacrocystorhinostomy;
  • external levator resection;
  • eyelid lesion removal and/or biopsy;
  • eyelid reconstruction and defect repair including after Mohs surgery;
  • fat pad excision (upper and lower lids);
  • gold or platinum weight implantation;
  • internal levator resection;
  • lateral tarsal strip;
  • orbital fracture repair requiring periorbital incisions;
  • orbitotomy requiring periorbital incisions;
  • tarsorrhaphy;
  • wedge excision.
  • Patients undergoing repeat procedures will also be included.

You CAN'T join if...

  • Patients aged younger than 18 years old who are undergoing the above eyelid procedures in an office, ambulatory care centers, operating rooms;
  • patients undergoing chalazion removal;
  • patients who have had previous wound infections at the site of the procedure;
  • patients with oral or IV antibiotic use within 10 days prior to procedure;
  • patients requiring IV antibiotics during the procedure;
  • patients with grossly contaminated or inflamed wounds;
  • patients with human or animal bites, patients with wounds resulting from trauma
  • patients allergic to all study drug options.


  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States

Lead Scientist

  • Robert Kersten
    Professor, Ophthalmology. Authored (or co-authored) 173 research publications


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Phase 4
Study Type
Last Updated