Epilepsy clinical trials at UCSF
24 in progress, 9 open to eligible people
Epilepsy is when the brain has abnormal electrical activity causing seizures. UCSF is studying treatments for Dravet Syndrome and difficult epilepsy cases with neuron cell therapy. Another trial looks at electrical brain stimulation effects on seizures.
ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
open to eligible people ages 6 months to 47 months
ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to <36 months (Part 1) and aged ≥6 to <48 months (Part 2). Part 1 follows an open-label,…
San Francisco, California and other locations
NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
open to eligible people ages 18-75
This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001), into both temporal lobes of subjects with…
San Francisco, California and other locations
EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
open to eligible people ages 2 years and up
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Dravet syndrome.
San Francisco, California and other locations
(PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
open to eligible people ages 12 years and up
The purpose of this study is to assess the efficacy, safety, PK, and PD of satralizumab in participants with NMDAR and LGI1 encephalitis.
San Francisco, California and other locations
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
open to eligible people ages 18-75
This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or …
San Francisco, California and other locations
Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)
open to eligible people ages 18 years and up
The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up.
San Francisco, California and other locations
Model-based Electrical Brain Stimulation
open to eligible people ages 18 years and up
Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them. Also, millions of patients do not respond to current medications or psychotherapy, which makes it critical…
San Francisco, California and other locations
CNKSR2 Natural History Study
open to eligible people ages 6-21
This prospective natural history study is being conducted to define the electroclinical, neurodevelopmental, and behavioral characteristics of CNKSR2 epilepsy aphasia syndrome (EAS) and intellectual disability (ID) in children aged 6 to 21 years old …
San Francisco, California
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
open to all eligible people
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal…
San Francisco, California and other locations
Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome
Sorry, in progress, not accepting new patients
The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of seizures in children and adults with Dravet Syndrome (DS) or Lennox-Gastaut Syndrome (LGS). Participants will receive their standard…
San Francisco, California and other locations
STK-001 for Patients With Dravet Syndrome
Sorry, accepting new patients by invitation only
Stoke Therapeutics is evaluating the long-term safety & tolerability of repeated doses of STK-001 in patients with Dravet syndrome who previously participated in studies of STK-001. Change in seizure frequency and overall clinical status, and…
San Francisco, California and other locations
Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age
Sorry, not currently recruiting here
Dravet syndrome is a genetic epilepsy associated with pathogenic variants in SCN1A that codes for Nav1.1, a protein necessary for sodium channels. Children with Dravet syndrome classically present in the first year of life with prolonged seizures,…
San Francisco, California and other locations
Epilepsy Cycles Longitudinal Monitoring to Inform Personalized Seizure-risk Estimation (ECLIPSE)
Sorry, accepting new patients by invitation only
The occurrence of seizures in epilepsy is not entirely random. Temporal patterns that organize the occurrence of seizures over weeks and months were previously unraveled using intracranial EEG System (IEEG) that monitors epileptic brain activity…
San Francisco, California
Evaluate How Safe and Tolerable NBI-921352 is as an Adjunctive Therapy for Participants With SCN8A-DEE
Sorry, accepting new patients by invitation only
Extension study to evaluate how safe and tolerable the drug NBI-921352 is when used as adjunctive therapy in participants with SCN8A developmental and epileptic encephalopathy syndrome (SCN8A-DEE).
San Francisco, California and other locations
Functional Organization of the Superior Temporal Gyrus for Speech Perception
Sorry, accepting new patients by invitation only
The basic mechanisms underlying comprehension of spoken language are still largely unknown. Over the past decade, the study team has gained new insights to how the human brain extracts the most fundamental linguistic elements (consonants and vowels) …
San Francisco, California
Neural Mechanisms for Stopping Ongoing Speech Production
Sorry, accepting new patients by invitation only
Speech and communication disorders often result in aberrant control of the timing of speech production, such as making improper stops at places where they should not be. During normal speech, the ability to stop when necessary is important for…
San Francisco, California
RNS System LGS Feasibility Study
Sorry, in progress, not accepting new patients
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or older with Lennox…
San Francisco, California and other locations
Spatiotemporal Dynamics of the Human Emotion Network
Sorry, accepting new patients by invitation only
The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms.…
San Francisco, California
NBI-921352 as Adjunctive Therapy in Subjects With SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE)
Sorry, in progress, not accepting new patients
The objective of this study is to assess the efficacy, safety, and pharmacokinetics of NBI-921352 as adjunctive therapy for seizures in subjects with SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE).
San Francisco, California and other locations
Neural Coding of Speech Across Human Languages
Sorry, accepting new patients by invitation only
The overall goal of this study is to reveal the fundamental neural mechanisms that underlie comprehension across human spoken languages. An understanding of how speech is coded in the brain has significant implications for the development of new…
San Francisco, California
Role of Inflammation in Neonatal Epileptogenesis
Sorry, in progress, not accepting new patients
The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.
Oakland, California and other locations
Human Epilepsy Project 3
Sorry, in progress, not accepting new patients
By carrying a careful, large-scale and ambitious prospective study of a cohort of participants with generalized epilepsy, the study team hopes to clarify the likelihood of response and remission in this type of epilepsy, and try to explore the…
San Francisco, California and other locations
RNS® System Epilepsy Post-Approval Study
Sorry, in progress, not accepting new patients
The purpose of the study is to follow patients with partial onset seizures prospectively over 5 years in the real-world environment to gather data on the long-term safety and effectiveness of the RNS System at qualified CECs by qualified…
San Francisco, California and other locations
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
Sorry, accepting new patients by invitation only
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12 months after injury.
San Francisco, California and other locations
Our lead scientists for Epilepsy research studies include Edward F Chang, MD Ernesto Gonzalez-Giraldo, MD Joseph Sullivan Robert Knowlton Lingyun Zhao, PhD Adam L Numis, MD Hannah C Glass, MDCM, MAS Jeffrey Gelfand Virginia Sturm, PhD.
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