for people ages 18-55 (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Principal Investigator
by Saam Morshed
Photo of Saam Morshed
Saam Morshed



The overall objective of this study is to compare outcomes following early advanced weight bearing (EAWB) using the AlterG antigravity treadmill versus standard of care physical therapy for adult patients with lower extremity periarticular injuries.

Official Title

Early Advanced Weight Bearing for Peri-articular Knee and Pilon Injuries: An RCT Using the Anti-Gravity Treadmill (AlterG)


Distal Femur Fracture Tibial Plateau Fracture Distal Tibia Fracture Pilon Fracture anti-gravity Fractures, Bone Femoral Fractures Tibial Fractures AlterG anti-gravity treadmill Early Advanced Weight Bearing (EAWB)


You can join if…

Open to people ages 18-55

  • Ages 18-55
  • Closed or Open (Gustilo Type I, II or IIIA) fractures: Distal femur (AO/OTA 33B, 33C), tibial plateau (AO/OTA 41B, 41C), or Distal tibia/pilon (AO/OTA 43B, 43C)
  • Definitively treated with a plate
  • Ambulatory prior to injury
  • Able to participate in rehab starting 28 days after definitive fixation
  • Meets AlterG requirements (4'8- 6'4; 85-400lbs)

You CAN'T join if...

  • Medical or psychological disease that would preclude safe functional testing (e.g., severe traumatic brain injury, stroke, heart disease, etc.)
  • Prior joint trauma or disease of the operative extremity that resulted in pain, stiffness, or other limitation to mobility
  • Injury to the contra-lateral limb, upper extremities or axial skeleton that would influence single limb weight-bearing or use of an assistive device
  • Pregnancy
  • Unable to speak English
  • Severe problems with maintaining follow-up (e.g. patients who are prisoners, homeless at the time of injury, who are intellectually challenged without adequate family support, or have documented psychiatric disorders).
  • Unable to provide informed consent.


  • University of California at San Francisco accepting new patients
    San Francisco California 94110 United States
  • Naval Medical Center San Diego accepting new patients
    San Diego California 92134 United States

Lead Scientist at UCSF

  • Saam Morshed
    Professor, Orthopaedic Surgery. Authored (or co-authored) 140 research publications. Research interests: trauma systems · poly-trauma · post-traumatic arthritis · global health.


accepting new patients
Start Date
Completion Date
Major Extremity Trauma Research Consortium
Study Type
Last Updated