Not currently recruiting at UCSF

X-linked Hypophosphatemia Disease Monitoring Program

a study on X-linked Hypophosphatemia Hypophosphatemic Rickets

Summary

at San Francisco, California and other locations
study started
estimated completion:

Description

Summary

The objectives of this observational study are to characterize XLH disease presentation and progression and to assess long-term effectiveness and safety of burosumab.

Official Title

X-linked Hypophosphatemia Disease Monitoring Program (XLH-DMP)

Details

The XLH-DMP is a global, prospective, multicenter, longitudinal, long-term outcomes program for subjects on or off treatment designed to characterize XLH disease presentation and progression, assess long-term safety and effectiveness of burosumab, as well as prospectively investigate longitudinal change over time across biomarker(s), clinical assessments, and patient/caregiver-reported outcome measures in a representative population. The XLH-DMP will collect demographic, biochemical, physiologic, disease severity, and progression data in patients taking burosumab and those not taking burosumab. In this DMP, patients will only have access to burosumab through authorized prescribed use. The Sponsor will not provide any treatments as part of the DMP.

Keywords

X-linked Hypophosphatemia Hypophosphatemic Rickets Fibroblast growth factor 23 (FGF23) KRN23 XLH Hypophosphatemia Familial Hypophosphatemic Rickets FGF23 Crysvita Rickets Rickets, Hypophosphatemic No intervention

Eligibility

You can join if…

  • Willing and able to provide informed consent or, in the case of patients under the age of 18 years (or 16 years, depending on the region), provide assent (if required) and informed consent by a legally authorized representative after the nature of the study has been explained, and prior to any research-related procedures.
  • Clinical diagnosis of XLH based on family history, OR confirmed PHEX mutation, OR biochemical profile consistent with XLH.
  • Willing and able to comply with the study visit schedule and study procedures.

You CAN'T join if...

  • Concurrent enrollment in an Ultragenyx-sponsored clinical trial is NOT permitted.
  • Serious medical or psychiatric comorbidity.
  • Less than five years of life expectancy.

Locations

  • University of California San Francisco not yet accepting patients
    San Francisco California 94158 United States
  • Children's Hospital of Colorado accepting new patients
    Aurora Colorado 80045 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Ultragenyx Pharmaceutical Inc
ID
NCT03651505
Study Type
Observational
Last Updated
August 28, 2018