for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion:
Nina Riggins



RCT of Sphenopalatine Ganglion (SPG) Blocks using anesthetics vs. placebo for migraine.

Official Title

UCSF Sphenopalatine Ganglion Block Study- a Randomized Double Blind Placebo Controlled Trial to Compare Nasal Anesthetics for Migraine Prevention in Adults.


Migraine is a disabling brain disorder with high prevalence. SPG blocks are widely used as an acute treatment of migraine; although the preventive effects have not been widely studied.

The sphenopalatine ganglion is located in the pterygopalatine ganglia close to the sphenopalatine foramen and is located below the maxillary nerve as it crosses the fossa. The sphenopalatine ganglion has multiple connections to facial, trigeminal, parasympathetic and sympathetic systems.

Due to the unique location it is possible to interrupt a pain signal by administering SPG blocks. As with many other preventive treatments, it appears to take up to 3-4 months to see long term headache benefit.


Migraine Migraine Disorders Lidocaine Ropivacaine Bupivacaine Anesthetics Marcaine or Ropivacaine


You can join if…

Open to people ages 18 years and up

  1. Current patients in the UCSF Headache Center who wish to receive SPG blocks for migraine and would otherwise receive treatment clinically
  2. Ability to provide consent for the research study
  3. Able to read and understand English

You CAN'T join if...

  1. Patients who cannot read and understand English
  2. Deemed unsuitable for enrollment in study by the investigator
  3. Allergy to lidocaine, marcaine, ropivacaine, anesthetics, or saline


  • UCSF Headache Center not yet accepting patients
    San Francisco California 94115 United States

Lead Scientist


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Phase 2
Study Type
Last Updated