for females ages 18-43 (full criteria)
Healthy Volunteers
healthy people welcome
at San Francisco, California
study started
estimated completion
Principal Investigator
by Heather Huddleston, MD
Headshot of Heather Huddleston
Heather Huddleston



Randomized control trial to determine if performing the US Health and Human Services recommended amount of weekly physical activity during ovarian stimulation will differentially affect mental health or clinical outcomes of individuals who are usually active, insufficiently active, or inactive in their everyday lives. The goal overall is to assess for safety and value of physical activity during fertility treatment.


Consenting participants will be separated into groups based on current average level of physical activity: Active women (complete >75 minutes of vigorous exercise or >150 minutes of moderate exercise per week) and Insufficiently active women (<75 minutes of vigorous exercise or <150 minutes of moderate exercise per week).

Between time of study enrollment and first ultrasound at start of ovarian stimulation cycle, the participants will be sent a link to questionnaires to assess general mental health parameters and physical fitness. They will be asked to complete the questionnaire prior to first ultrasound visit. At time of first ultrasound, participants who have completed the pre-stimulation survey will be randomized into one of two arms depending on their group: the active group will be randomized to (A) maintenance or (B) decreased activity arm, and the insufficiently active group will be randomized to (C) increased or (D) maintenance activity arm.

Also at first ultrasound, participants will be given a wearable heart rate monitor in order to track heart rate during the time from ovarian stimulation to first pregnancy test in order to monitor compliance to randomized activity level of each participant. The data from the monitors will be collected through a central university provided, password protected laptop utilizing an app platform. Furthermore, all participants will be asked to complete a daily mood, stress, discomfort questionnaire throughout stimulation. Participants will be expected to continue recommended physical activity level and questionnaires until day of egg retrieval. Wearable monitors will continue to be worn until time of first pregnancy test. Within the two weeks after completion of egg retrieval, participants will be sent a follow-up questionnaire to assess overall treatment stress and satisfaction with ovarian stimulation cycle. Those who completed in vitro fertilization and fresh embryo transfer will be sent a second follow-up questionnaire about 1-2 weeks after pregnancy test.


Infertility, Female, Physical Activity, In Vitro Fertilization, Ovarian Stimulation, Exercise, Infertility, Female Infertility, Sufficient physical activity, Insufficient physical activity, Usually Insufficiently Inactive- Increase, Usually Insufficiently Inactive- Maintenance


You can join if…

Open to females ages 18-43

  • First ovarian stimulation cycle for egg freezing or for in vitro fertilization
  • English speaking/reading
  • Patient at the Center for Reproductive Health, University of California San Francisco

You CAN'T join if...

  • Serious health conditions that limit amount of physical activity
  • BMI>40


  • UCSF Medical Center at Mission Bay accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Heather Huddleston, MD
    Dr. Heather Huddleston is a specialist in reproductive endocrinology (hormonal function) and infertility. She cares for patients with a wide array of reproductive and fertility concerns. She has special interests in polycystic ovary syndrome (PCOS), recurrent pregnancy loss and uterine disorders, including Asherman's syndrome (a condition involving scar tissue in the uterus).


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 600 study participants
Last Updated