for people ages 18-85 (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Ying Han, MD, PhDThuy Doan, MD, PhD
Headshot of Ying Han
Ying Han
Headshot of Thuy Doan
Thuy Doan



In this study, the investigators seek to determine the effect of antibiotic use post-surgery on antimicrobial resistance. The investigators will be studying adults (aged 18 or older) who will undergo eye surgery at University of California, San Francisco (UCSF). We seek to gain a better understanding of how antibiotic use during the perioperative period influences local and systemic antibiotic resistance at the individual level.

Official Title

Antibiotic Resistance In Eye Surgeries (ARIES)


Antibiotic use has saved millions of lives globally. However, this comes at the cost of selecting for antibiotic-resistant organisms at the individual and the community level. It is estimated that every year, approximately 700,000 deaths are associated with drug resistance globally. This places a significant burden on the public health system and the judicious use of antibiotics is more important than ever before.

The proposed masked, randomized controlled trial evaluates the effects of topical antibiotic use on the selection of antibiotic resistance determinants at the local and systemic levels. The results will provide guidance for antibiotic usage in ophthalmology and may have the potential to inform public health policies.


Antibiotic Resistance, Ocular Surface Microbiome, Gut Resistome, Moxifloxacin, Moxifloxacin (Topical), Intraoperative antibiotics (Abx); Postoperative topical antibiotics four times a day for 1 week


You can join if…

Open to people ages 18-85

  1. Over 18 years of age
  2. Undergoing cataract surgeries that would benefit from intracameral antibiotics
  3. Able to provide swabs
  4. Able to provide consent
  5. Surgery of the second eye occurs at least 8 weeks after surgery of the first eye

You CAN'T join if...

  1. Same-day bilateral cataract surgeries
  2. On immunosuppression medication such as Prednisone, Methotrexate, Cellcept, or anti-TNF inhibitors within past 3 months
  3. On systemic antibiotic within past 3 months
  4. On topical antibiotics within past 8 weeks
  5. Allergies to fluoroquinolone
  6. Patients needing glaucoma drainage device or trabeculectomy
  7. Inability to consent


  • UCSF accepting new patients
    San Francisco California 94158 United States

Lead Scientists at UCSF

  • Ying Han, MD, PhD
    Dr. Ying Han is an ophthalmologist who specializes in treating glaucoma, including medical, laser and surgical therapies. She has expertise in evaluating and treating cataracts as well. In her research, Han evaluates new drug delivery and new surgical procedures for glaucoma. She's also interested in screening and treatment of glaucoma to prevent vision loss.
  • Thuy Doan, MD, PhD
    Associate Professor, Proctor Foundation, Chancellor/EVC/FAS. Authored (or co-authored) 111 research publications


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Phase 4 research study
Study Type
Expecting 108 study participants
Last Updated