Congenital Heart Defects clinical trials at UCSF
7 in progress, 5 open to eligible people
Congenital heart defects are issues with how the heart is formed at birth. UCSF is exploring a special heart valve to treat patients with valve dysfunction safely. They study two methods to enhance blood flow in infants with specific heart needs. UCSF is also evaluating tools to determine how accurately they read oxygen levels in diverse skin types.
Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
open to all eligible people
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will…
Oakland, California and other locations
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
open to all eligible people
This study will demonstrate the safety and effectiveness of the Edwards Lifesciences SAPIEN 3/SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve (THV) Systems in subjects with a dysfunctional right ventricular outflow tract (RVOT) conduit or…
San Francisco, California and other locations
Improving Congenital Heart Disease Care
open to eligible people ages 18 years and up
The theory-informed digital health intervention, called as "Empower My Congenital Health (EmpowerMyCH)" aims to activate and engage ACHD patients in building confidence toward navigating the adult healthcare system. This tool is built after…
San Francisco, California
Fetal Aortic Valvuloplasty on Outcomes
open to all eligible people
In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects. The underdevelopment can occur gradually during fetal…
San Francisco, California and other locations
Evaluating Pulse Oximetry Bias in Children With Darker Skin Pigmentation
open to eligible people ages up to 21 years
In this prospective study, the investigators will enroll 154 children with arterial lines to determine the accuracy of pulse oximeters in children with darker skin pigmentation. Studies in adults suggest pulse oximeters may overestimate the true…
Palo Alto, California
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
Sorry, in progress, not accepting new patients
To demonstrate the safety and effectiveness of the Edwards Alterra Adaptive Prestent in conjunction with the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) System in subjects with a dysfunctional right ventricular outflow tract/pulmonary valve…
San Francisco, California and other locations
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
Sorry, not currently recruiting here
Determine 1) the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay (ND) outcomes and 2) how this relationship is modified by patient and environmental factors such as chronic congenital heart disease (CCHD) lesion,…
San Francisco, California and other locations
Our lead scientists for Congenital Heart Defects research studies include Jeffery Meadows, MD Anushree Agarwal, MBBS, MAS Shabnam Peyvandi, MD.
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