for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
completion around
Principal Investigator
by Liviu Klein, MD
Headshot of Liviu Klein
Liviu Klein



The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop diuretics in patients with worsening heart failure (HF) and fluid overload.

Official Title

A Randomized Controlled Study to Evaluate the Safety and Effectiveness of the Aquadex System in Patients With Heart Failure and Fluid Overload


Heart Failure (for Example, Fluid Overload), Heart failure, Fluid overload, Diuretics, Sodium Potassium Chloride Symporter Inhibitors, Aquadex Smartflow® System, IV Loop Diuretics, Aquadex ultrafiltration therapy


You can join if…

Open to people ages 18 years and up

  • 18 years or older
  • Man, or non-pregnant woman
  • Admitted to the hospital with a diagnosis of acute decompensated heart failure
  • On regularly prescribed oral loop diuretics, Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors or a Mineralcorticoid Receptor Antagonists (MRA) prior to admission
  • Fluid overload manifested by at least three clinical indications (e.g., edema, an excess of at least 10 pounds of fluid, etc.)
  • Provide written informed consent

You CAN'T join if...

  • New diagnosis of heart failure
  • Acute coronary syndromes
  • Creatinine ≥ 3.0 mg/dl or planned renal replacement therapies at the time of enrollment
  • Contraindications to systemic anticoagulation
  • Severe concomitant disease expected to prolong hospitalization or cause death in less than 90 days
  • Sepsis or ongoing systemic infection
  • Active myocarditis
  • Constrictive pericarditis or restrictive cardiomyopathy
  • Severe aortic stenosis
  • Any condition in the opinion of the investigator that would prevent the patient from follow-up/survival


  • UCSF accepting new patients
    San Francisco California 94143 United States
  • MemorialCare, Long Beach Medical Center accepting new patients
    Long Beach California 90806 United States

Lead Scientist at UCSF

  • Liviu Klein, MD
    My are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies.


accepting new patients
Start Date
Completion Date
Nuwellis, Inc.
Study Type
Expecting 372 study participants
Last Updated