for people ages 18 years and up (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Rita Mukhtar, MD
Headshot of Rita Mukhtar
Rita Mukhtar



This is a prospective observational registry for patients with invasive lobular carcinoma (ILC) of the breast. After the first 1cohort is enrolled, the collected data will be utilized to develop an ILC specific response assessment tool.

Official Title

Improving Survival for Those With Metastatic Lobular Breast Cancer Through Development of the Multi-center PLUMB Registry-a Prospective Study of LobUlar Metastatic Breast Cancer


Primary Aims:

  1. To evaluate the feasibility of developing a histologic based registry for participants living with metastatic lobular breast cancer.
  2. To understand the natural history, treatment patterns, and overall survival in patients with metastatic ILC using modern, real-world data.

Secondary Aims:

  1. To evaluate the correlation between imaging findings and disease progression.
  2. To evaluate the correlation between ctDNA and disease progression.
  3. To develop an ongoing platform for evaluating new imaging tools, tumor markers, and participant recruitment for clinical trials.


Participants will be recruited to participate in the registry during a regularly scheduled clinic visit with their treating oncologist, and consented to participate at this time. At each evaluation time point, participants will have a blood draw performed. Participants will be followed until loss to follow up, death, or withdrawal from the registry.


Metastatic Breast Cancer, Lobular Breast Carcinoma, Breast Neoplasms, Lobular Carcinoma, Blood Specimen


You can join if…

Open to people ages 18 years and up

  1. Histologically confirmed invasive lobular carcinoma. Mixed lobular/ductal cancer is allowed.
  2. Age >=18 years
  3. Any receptor subtype.
  4. Ability to understand a written informed consent document, and the willingness to sign it.

You CAN'T join if...

  1. Stage I-III breast cancer.
  2. Lack of lobular histology on tumor biopsy.
  3. Other active cancer (prior treated cancer with no current evidence of disease is allowed).


  • UCSF accepting new patients
    San Francisco California 94122 United States

Lead Scientist at UCSF

  • Rita Mukhtar, MD
    Dr. Rita Mukhtar specializes in breast surgery and general surgery for urgent conditions. For her patients with breast cancer, she offers expertise in total skin-sparing mastectomies, breast conservation, wire localization surgery (used to show the location of tissue requiring biopsy) and sentinel lymph node biopsy (used to see if cancer has spread).


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Observational [Patient Registry]
Expecting 12 study participants
Last Updated