Summary

Eligibility
for people ages 18-90 (full criteria)
Location
at San Francisco, California and other locations
Dates
study started
completion around

Description

Summary

A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression.

The goal of the investigators is to recruit a group of patients with RA-ILD and collect information to help us understand more about disease progression. The investigators will do this using a combination of clinical, radiologic, and biologic features.

Official Title

Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease (MOUNTAIN)

Details

The central hypothesis is that novel quantitative imaging and specific blood markers will be associated with progressive RA-ILD. The hypothesis will be tested through collection and analysis of peripheral blood, in addition to the analysis of HRCT (high-resolution computed tomography) scans performed as standard of care (clinical) on research subjects.

Procedures performed:

Baseline Year 0: Blood sample, buccal (cheek) swab, questionnaires and if performed clinically - Pulmonary Function tests, 6 Minute Walk Test, and HRCT scan of lungs

Every 4 months (at clinic visit): Blood sample, questionnaires

Year 1 and Year 2 Follow-ups: Blood sample, buccal (cheek) swab, questionnaires and if performed clinically - Pulmonary Function tests, 6 Minute Walk Test, and HRCT scan of lungs

Keywords

Rheumatoid Arthritis, Interstitial Lung Disease, Lung Diseases, Interstitial Lung Diseases, Research Testing Performed (Laboratory), Research Testing Performed

Eligibility

You can join if…

Open to people ages 18-90

  • Multidisciplinary diagnosis of RA-ILD based on the 2010 American College of Rheumatology criteria
  • 18 years of age or older

You CAN'T join if...

  • Prior medication treatment specifically for RA-ILD
  • Inability to give informed consent
  • Pregnant women

Locations

  • UCSF accepting new patients
    San Francisco California 94143 United States
  • University of Colorado Denver accepting new patients
    Aurora Colorado 80045 United States
  • University of Kansas accepting new patients
    Kansas City Kansas 66103 United States
  • University of Michigan accepting new patients
    Ann Arbor Michigan 48109 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of Colorado, Denver
ID
NCT06397677
Study Type
Observational [Patient Registry]
Participants
Expecting 450 study participants
Last Updated