This study is not yet accepting patients

The ROAR Study: Reactive Oxygen Species and Reproduction

a study on Ovarian Aging In Vitro Fertilization Oxidative Stress

Summary

Eligibility
for people ages 18-43 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
study ends around
Principal Investigator
by Mitchell Rosen, MD

Description

Summary

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Keywords

Ovarian Aging, IVF Outcome, Oxidative Stress, Oxidative stress markers, Couples undergoing IVF

Eligibility

You can join if…

Open to people ages 18-43

  1. Female age 18-43 years
  2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
  3. Male partners 18 years of age or older.
  4. Must be a registered patient at UCSF Center for Reproductive Health
  5. Patient and partner must both be physically present on the day of retreival

You CAN'T join if...

  1. Female partner age 44 or older
  2. Planning fresh transfer (hybrid PGS cycle)
  3. Cleavage stage biopsy
  4. Planning to use frozen sperm

Location

  • UCSF
    San Francisco California 94158 United States

Lead Scientist at UCSF

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT06831019
Study Type
Observational
Participants
Expecting 1100 study participants
Last Updated