Vaping clinical trials at UCSF
4 in progress, 1 open to eligible people
Vaping is using an electronic device to inhale nicotine. UCSF is studying how different vaping behaviors affect the body and the chemicals people are exposed to. One trial is looking at how nicotine from e-cigarettes is absorbed and its effects on health.
Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
open to eligible people ages 21-70
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.
San Francisco, California
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
Sorry, not yet accepting patients
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25. The main question it aims to answer is: will cannabis users who switch to less potent THC products demonstrate improved cognitive function compared to baseline? Other questions this study aims to answer include: - Can researchers accurately assess THC consumption among frequent cannabis users? - Can researchers effectively incentivize cannabis users to use less potent THC products? - Do genetic variations in THC metabolism impact urinary THC excretion? - Do genetic variations in THC metabolism impact cognitive performance in cannabis users? - Are quantitative urinary THC values predictive of cognitive impairment? - How can researchers use research findings to inform harm reduction practices for people who use cannabis? Participants will submit blood and urine samples and be incentivized to use less potent THC products.
San Francisco, California
Pharmacodynamics of Synthetic Nicotine
Sorry, not yet accepting patients
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
San Francisco, California
Clinical Pharmacology of Marijuana-Tobacco Co-administration
Sorry, not yet accepting patients
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.
San Francisco, California
Our lead scientists for Vaping research studies include Gideon St Helen Veronika Mesheriakova, MD Neal Benowitz, MD.
Last updated: