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Summary

for people ages 18 years and up
at San Francisco, California and other locations
study started
estimated completion:

Description

Summary

The purpose of this study is to collect clinical and epidemiological data as well as serum, plasma, urine, tissue and DNA samples on individuals who have acute liver failure and on individuals who have acute liver injury, a less severe group of patients who have coagulopathy but do not reach the threshold of encephalopathy.

Details

Although ALF is truly an orphan disease affecting only about 2,000 persons per year, its severity, its frequency among young adults, and its high resource utilization justifies the attention paid to it. In addition, ALF has captured the interest and attention of researchers because of its unique pathogenesis and extreme severity, encouraging us to understand the processes underlying all forms of liver injury, by focusing on this most lethal manifestation.

The etiologies associated with ALF have continued to change further over the years with an apparent decline in viral hepatitis, and a remarkable increase in acetaminophen toxicity to its current level of ~44-50% of cases. A further problem in studying ALF is that the number of cases of a specific etiology observed at any one institution are vanishingly small. The earliest goals of the ALF Study then were to more carefully define the etiologies of ALF on a national scale, and to finally allow in-depth study of specific ALF causes such as autoimmune ALF, viral hepatitis and Wilson disease (WD).

A second group of patients worthy of study are those with acute liver injury.It would be of value to study patients destined to possibly have ALF earlier in their illness for several reasons: first, we might be able to better predict who will progress to full liver failure; second, the current definition requiring encephalopathy limits the number of patients available for study at any site; finally, therapeutic trials might have greater efficacy if begun at earlier disease stages.

Patients who are enrolled are referred to ALFSG clinical sites by gastroenterologist/hepatologist and fellows. Detailed clinical data and bio-specimen (sera, urine, plasma, DNA and tissue if available) are collected. Subjects are followed long-term at 6 months and 12 months. Detailed clinical data and sera are collected.

Keywords

Acute Liver Failure Fulminant Hepatic Failure Acute Liver Injury Liver disease Liver injury

Eligibility

For people ages 18 years and up

ALF Inclusion Criteria:

  • Written Informed consent from patient's next of kin
  • Altered mentation of any degree (encephalopathy)
  • Evidence of moderately severe coagulopathy (INR ≥ 1.5)
  • A presumed acute illness onset of less than 26 weeks
  • The NIH guidelines on the inclusion of women and minorities as subjects in clinical research will be observed

ALF Exclusion Criteria:

  • Cirrhosis patients
  • Alcohol induced liver failure
  • Known pre-existing chronic liver disease

ALI Inclusion Criteria:

Acetaminophen (APAP) etiology: acute illness < 2 wks

  • INR ≥ 2.0, ALT ≥ 10X ULN Non-acetaminophen etiology: acute illness < 26 wks
  • INR≥ 2.0, ALT≥ 10X ULN, TBili ≥ 3 mg/dl

ALI Exclusion Criteria:

• Altered mentation of any degree (encephalopathy)

Locations

  • University of Washington accepting new patients
    Seattle, Washington, 98195, United States
  • University of Alberta accepting new patients
    Edmonton, Alberta, Canada
  • University of Texas Southwestern Medical Center accepting new patients
    Dallas, Texas, 75390, United States
  • Kansas University Medical Center accepting new patients
    Kansas City, Kansas, 66160, United States
  • Northwestern University Medical School accepting new patients
    Chicago, Illinois, 60611, United States
  • University of Alabama at Birmingham accepting new patients
    Birmingham, Alabama, 35294, United States
  • University of Michigan Medical Center accepting new patients
    Ann Arbor, Michigan, 48109, United States
  • The Ohio State University accepting new patients
    Columbus, Ohio, 43210, United States
  • Emory University accepting new patients
    Atlanta, Georgia, 30322, United States
  • Medical University of South Carolina accepting new patients
    Charleston, South Carolina, 29425, United States
  • Virginia Commonwealth University accepting new patients
    Richmond, Virginia, 23298, United States
  • Yale Medical School accepting new patients
    New Haven, Connecticut, 06520, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
William Lee
Links
Acute Liver Failure Study Group website
ID
NCT00518440
Lead Scientist
Bilal Hameed
Study Type
Observational
Last Updated
October 1, 2016
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