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Asthma clinical trials at UCSF

15 in progress, 9 open to eligible people

Showing trials for
  • Blood Lymphocytes in Asthmatics Treated With Therapeutic Proteins

    open to eligible people ages 18-80

    This is an observational, clinic-based, single center study of 120 subjects. Participants will be comprised of patients seen in the outpatient faculty practice in ambulatory care at the UCSF Parnassus campus. Study investigators will enroll 20 healthy participants with no history of lung disease, 50 asthmatics who are newly prescribed therapeutic proteins for their asthma, and 50 asthmatics already being treated with therapeutic proteins for their asthma. Participants will be seen at 1 to 3 visits and provide blood samples at each visit.

    San Francisco, California

  • Characterization of Adult Subjects for Asthmatic Research Studies

    open to eligible people ages 18 years and up

    This study is designed to characterize subjects in terms of the nature and severity of their asthma and in terms of conditions that may alter the clinical expression of asthma. Some features will be obtained in all subjects. These include a medical history and baseline lung function tests. This characterization forms the basis for our database that facilitates research protocols.

    San Francisco, California

  • Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program

    open to eligible people ages 18-65

    This study is designed to characterize subjects in terms of their sputum phenotype. The purpose of this study is to learn more about the impact of having abnormally elastic sputum on asthma severity by comparing subjects with severe as well as mild/moderate asthma to healthy controls. The characterization will include medical history, pulmonary function testing, imaging of the lungs and biospecimen collection.

    San Francisco, California

  • PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

    open to eligible people ages 12 years and up

    The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.

    San Francisco, California and other locations

  • Pulmonary Specialist-Health Coach Consult Model Study

    open to eligible people ages 18 years and up

    The Pulmonary Specialist-Health Coach Consultation (PuSHCon) study examines the implementation of health coach-assisted consultations to improve access to specialist care and implementation of specialist recommendations for patients with COPD, asthma, and asthma COPD overlap syndrome (ACOS) for low-income and vulnerable patients seen at public health clinics. Three hundred sixty (360) patients from ten clinics will be enrolled in the study and randomized at the individual level to receive health coaching or usual care; 180 patients will receive usual care and 180 patients will receive the PuSHCon model.

    San Francisco, California and other locations

  • Severe Asthma Research Program

    open to eligible people ages 6 years and up

    The mission of the SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time. The ultimate goal of these efforts is to promote better treatments for severe asthma.

    San Francisco, California and other locations

  • Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)

    open to eligible people ages 18-70

    This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit. We will identify differences in airway epithelial epigenetic enhancer signatures in asthma, by analyzing freshly isolated airway epithelial cells from healthy controls and from well-characterized subjects with asthma.

    San Francisco, California

  • The Effect of NAC on Lung Function and CT Mucus Score

    open to eligible people ages 18-80

    This study evaluates 20% n-acetylcysteine (NAC) in the treatment of moderate-to-severe asthma that is complicated by mucus in the airway, as determined by CT imaging. The study is a crossover design, which means that half the study participants will get 20% NAC in the first 14-day treatment period and placebo in the next 14-day treatment period; and the other half will get placebo in the first 14-day treatment period and 20% NAC in the next 14-day treatment period.

    San Francisco, California

  • Tissue Immune Interaction in Nasal Polyposis

    open to eligible people ages 18-80

    This is a cross-sectional study of up to 100 subjects who are undergoing clinically indicated sinus procedures to treat chronic rhinosinusitis. Participants will be asked to donate leftover sino-nasal secretions, sino-nasal tissue and blood as well as undergo partial characterization. As optional extensions of the main study, participants may also undergo a biopsy of extra sino-nasal tissue for additional tissue analysis and/or a more detailed characterization visit performed in the UCSF Airway Center Research Center (ACRC).

    San Francisco, California

  • Inpatient Clinical Trial of NAC

    Sorry, in progress, not accepting new patients

    The purpose of this study is to determine the beneficial effect of n-acetylcysteine (NAC), an inhaled medication that breaks down mucus, on lung function. NAC is a medication approved by the US Food and Drug Administration (FDA) for the treatment of chronic diseases of the respiratory system, including asthma. With CT lung imaging, the investigators seek to identify a subgroup of patients with asthma with a 'mucus' profile. This is a single-arm study which means all participants will receive the same treatment.

    San Francisco, California

  • Mechanisms of Exacerbation of Asthma

    Sorry, in progress, not accepting new patients

    The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.

    San Francisco, California

  • Medication Adherence With Telehealthcare Medication Therapy Management

    Sorry, not currently recruiting here

    Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of Adolescents and Young Adults (AYA) with uncontrolled asthma who have poor adherence with prescribed Inhaled corticosteroid (ICS) therapy.

    San Francisco, California and other locations

  • Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness

    Sorry, in progress, not accepting new patients

    The primary objective of this study is to evaluate if Broncho-Vaxom® given to high risk infants for 10 days, monthly, for two consecutive years can increase time to occurrence of the first episode of wheezing lower respiratory tract illness (WLRI) during a three year observation period off therapy.

    Oakland, California and other locations

  • Study of Focal Airway Disease in Asthma Using Image Guided Bronchoscopy

    Sorry, not yet accepting patients

    This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" [VNB]) to sample airway biospecimens in mucus plugged and control airways.

    San Francisco, California

  • Use of a Probiotic Supplement to Prevent Asthma in Infants

    Sorry, in progress, not accepting new patients

    The goal of the study is to understand the mechanisms of how antigen presentation affects the developing immune system and subsequently affects susceptibility to, or protects against, asthma development. This randomized controlled study will test the effectiveness of daily supplementation of Lactobacillus GG for the first 6 months of life on the early immunological development of asthma.

    San Francisco, California

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