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Cardiomyopathy clinical trials at UCSF

14 in progress, 5 open to eligible people

Showing trials for
  • Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy

    open to eligible people ages 18 years and up

    The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).

    San Francisco, California and other locations

  • AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

    open to eligible people ages 18 years and up

    Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction (HFrEF).

    San Francisco, California and other locations

  • Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy

    open to eligible people ages 18-80

    The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnaires, 12 lead ecg's, biomarker levels, echocardiogram, Cardiac Magnetic resonance, PET and CPET will be performed to evaluate their response to the intervention.

    San Francisco, California

  • TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

    open to eligible people ages 18-65

    This is a first-in-human, non-randomized, open-label study designed to evaluate the safety, tolerability, and pharmacodynamics (PD) of TN-201 in adult patients with symptomatic MYBPC3 mutation-associated nonobstructive hypertrophic cardiomyopathy (nHCM).

    San Francisco, California and other locations

  • Evaluating Pulse Oximetry Bias in Children With Darker Skin Pigmentation

    open to eligible people ages up to 21 years

    In this prospective study, the investigators will enroll 154 children with arterial lines to determine the accuracy of pulse oximeters in children with darker skin pigmentation. Studies in adults suggest pulse oximeters may overestimate the true level of oxygenation in the blood as measured directly by co-oximetry. However, pediatric data are relatively limited. This study, which is funded by the FDA through the Stanford-UCSF (University of California San Francisco) Clinical Excellence in Regulatory Science and Innovation (CERSI) Program, will determine if the error/bias is associated with skin pigmentation and whether the error falls outside FDA standards. The broader purpose of the study is to work toward eliminating health disparities.

    Palo Alto, California

  • Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

    Sorry, in progress, not accepting new patients

    Approximately 30 sites that enrolled participants in the MAVERICK-HCM (MYK-461-006) study in the United States (US) will initiate this study. Approximately 90 sites that enrolled participants in the EXPLORER-HCM (MYK-461-005) study in the US, Europe, and Israel will initiate this study. Note: Approximately 30 centers overlap between MAVERICK and EXPLORER.

    San Francisco, California and other locations

  • IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy Trial

    Sorry, in progress, not accepting new patients

    The purpose of this study is to assess the safety, tolerability, and potential efficacy of IMB-1018972 in patients with non-obstructive HCM.

    San Francisco, California and other locations

  • CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

    Sorry, in progress, not accepting new patients

    To evaluate the efficacy of eplontersen compared to placebo in participants with ATTR-CM receiving available standard of care (SoC). For more information, please visit https://www.cardio-ttransform.com.

    San Francisco, California and other locations

  • Early Feasibility Evaluation of the AccuCinch® Ventricular Restoration System in Patients With Heart Failure and Reduced Ejection Fraction

    Sorry, in progress, not accepting new patients

    This is a non-randomized, prospective, multi-center Early Feasibility Study to evaluate the AccuCinch® Ventricular Restoration System in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF).

    San Francisco, California and other locations

  • Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation

    Sorry, in progress, not accepting new patients

    This is a non-randomized, prospective, multi-center Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients with Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation.

    San Francisco, California and other locations

  • Long-term Safety and Tolerability of Aficamten in Adults With HCM

    Sorry, accepting new patients by invitation only

    The purpose of this study is to collect long-term safety and tolerability data for aficamten (CK-3773274)

    San Francisco, California and other locations

  • AG10 in Patients With Cardiomyopathy

    Sorry, in progress, not accepting new patients

    This prospective, multicenter open-label study will evaluate the long-term safety, tolerability, PK and PD of AG10 administered on a background of stable heart failure therapy.

    San Francisco, California and other locations

  • ALXN2220 Versus Placebo in Adults With ATTR-CM

    Sorry, not yet accepting patients

    The primary objective of this study is to assess the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the composite endpoint of all-cause mortality (ACM) and total cardiovascular (CV) clinical events.

    San Francisco, California and other locations

  • IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

    Sorry, accepting new patients by invitation only

    This is a prospective multi-center international registry. The objective of this registry is to collect prospective data on patients undergoing catheter ablation for Ventricular Tachycardia (VT) and Premature Ventricular Contractions (PVC). The registry will be used for clinical monitoring, research, and quality improvement purposes.

    San Francisco, California and other locations

Our lead scientists for Cardiomyopathy research studies include .

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