Summary

for people ages 18-90 (full criteria)
at San Francisco, California and other locations
study started
estimated completion:

Description

Summary

This prospective, multicenter open-label study will evaluate the long-term safety, tolerability, PK and PD of AG10 administered on a background of stable heart failure therapy.

Official Title

An Open-Label Extension and Safety Monitoring Study of Patients With Symptomatic Transthyretin Cardiomyopathy Who Have Completed the Phase II Study AG10-201

Details

An Open-Label Extension and Safety Monitoring Study of Patients with Symptomatic Transthyretin Cardiomyopathy Who Have Completed the Phase II Study AG10-201

The primary objective of this study is to evaluate the long-term safety and tolerability of AG10 administered to adult patients with symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM) in patients who have completed the study AG10-201.

This study will be an Open-Label Extension and Safety Monitoring Study of up to 55 male and/or female patients with symptomatic ATTR-CM aged 18 through 90 years, who have completed the Phase II Study AG10-201. Enrollment into the study will be followed by visits at Day 14, Day 45, 3 Months and every 3 months thereafter. There will be one 7 to 14-day follow-up visit after last dose.

If all doses are well tolerated, the duration of each patient's participation in the study will continue based on periodic recommendations of the AG10 Data Monitoring Committee (DMC) and/or registration of the product for the treatment of symptomatic ATTR-CM.

The secondary objectives of this study are to characterize the pharmacokinetics (PK) of AG10 administered orally twice daily in patients with symptomatic ATTR-CM, and to describe the long-term pharmacodynamic (PD) properties of AG10 as assessed by established assays of transthyretin (TTR) stabilization, including Fluorescent Probe Exclusion (FPE) assay and Western blot, and to describe the PK-PD relationship of AG10 in adult patients with symptomatic ATTR-CM.

Keywords

Amyloid Cardiomyopathy Cardiomyopathies AG10 Open-Label

Eligibility

You can join if…

Open to people ages 18-90

  1. Completed participation in study AG10-201.
  2. Willing and able to comply with the study medication regimen and all study requirements.
  3. The ability to understand and provide informed consent, which must be obtained prior to initiation of study participation.
  4. Male patients and female patients of childbearing potential who engage in heterosexual intercourse must agree to use effective method(s) of contraception.

You CAN'T join if...

  1. Hemodynamic instability that would pose too great a risk to the subject.
  2. Abnormalities in clinical laboratory tests that would pose too great a risk to the subject.
  3. Any clinically significant ongoing medical condition or any laboratory abnormality or condition that could adversely affect the safety of the patient.
  4. Known hypersensitivity to study drug (AG10), its metabolites, or formulation excipients.
  5. Likely to undergo heart transplantation or placement of a mechanical circulatory device within the next year.
  6. Receiving current treatment with diflunisal, tafamidis, green tea, doxycycline,TUDCA/Ursodiol, patisiran, inotersen or any other investigational ATTR agent within 14 days or 5 half-lives of the prior investigational agent (whichever is longer) prior to dosing with study drug.
  7. Females who are pregnant or breastfeeding. Lactating females must agree to discontinue nursing before the study drug is administered.

Locations

  • University of California San Francisco
    San Francisco California 94143 United States
  • Stanford University
    Palo Alto California 94304 United States

Details

Status
accepting new patients by invitation only
Start Date
Completion Date
(estimated)
Sponsor
Eidos Therapeutics
ID
NCT03536767
Phase
Phase 2
Study Type
Interventional
Last Updated