Skip to main content

Chronic Lung Allograft Dysfunction clinical trials at UCSF

3 research studies open to eligible people

Showing trials for
  • Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1)

    open to eligible people ages 18 years and up

    The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in single lung transplant recipients.

    San Francisco, California and other locations

  • Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2)

    open to eligible people ages 18 years and up

    The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in double lung transplant recipients.

    San Francisco, California and other locations

  • Inhaled Sirolimus in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome.

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to learn about the safety and effectiveness of inhaled sirolimus in patients who have developed bronchiolitis obliterans syndrome (BOS), a form of chronic rejection, after lung transplantation. The main questions it aims to answer are: - Is inhaled sirolimus safe in these patients? - Is inhaled sirolimus effective in slowing BOS progression? Participants will: - Be randomly assigned to inhale either sirolimus or placebo (a look-alike substance that contains no active drug) daily for 48 weeks - Attend 10 study visits (mixture of in-person and telehealth) over the 48 week period - Undergo pulmonary function testing, bronchoscopy, lab testing, and physical examination - Submit weekly home spirometry monitoring Researchers will compare participants assigned to inhaled sirolimus versus placebo to see if sirolimus is safely tolerated and to assess the effectiveness of inhaled sirolimus on slowing BOS progression.

    San Francisco, California

Our lead scientists for Chronic Lung Allograft Dysfunction research studies include .

Last updated: