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Mild Cognitive Impairment clinical trials at UCSF

13 in progress, 9 open to eligible people

Mild cognitive impairment involves having more memory problems than normal for one's age. UCSF is exploring how digital tools combined with brain stimulation might enhance cognitive abilities. They are also investigating if music training can improve cognitive function in older adults. Additionally, UCSF is studying digital interventions to boost attention and wellbeing.

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  • Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation

    open to eligible people ages 60-85

    The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation …

    San Francisco, California

  • Enhancing Attention and Wellbeing Using Digital Therapeutics

    open to eligible people ages 60-99

    The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e.,…

    San Francisco, California

  • Music Improvisation Training on Cognitive Function in Older Adults

    open to eligible people ages 60 years and up

    This project will study the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI. The investigator's overall hypothesis is that improvisation training will lead to improvements …

    San Francisco, California and other locations

  • Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults

    open to eligible people ages 60-85

    The goal of this proposed research is to collect pilot data to test the hypothesis that treatment with a novel form of closed-loop digital meditation (MediTrain) will lead to a greater magnitude of gains in cognitive abilities in patients with mild…

    San Francisco, California

  • Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

    open to eligible people ages 55-89

    Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination …

    San Francisco, California and other locations

  • Wayfinding Intervention and Long-Term Memory

    open to eligible people ages 60-85

    Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive…

    San Francisco, California

  • Alzheimer's Disease Neuroimaging Initiative 4

    open to eligible people ages 55-90

    Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2,…

    San Francisco, California and other locations

  • Longitudinal Early-onset Alzheimer's Disease Study Protocol

    open to eligible people ages 40-64

    The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging,…

    San Francisco, California and other locations

  • Remote Cognitive Assessment for Surgical Patients

    open to eligible people ages 65-99

    This is a pilot study to evaluate the use of remote cognitive testing to identify patients who may have cognitive vulnerability and may benefit from cognitive care pathways. Participants in this study are asked to complete a smartphone battery of…

    San Francisco, California

  • Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

    Sorry, in progress, not accepting new patients

    In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD. The main question researchers are trying to answer is if BIIB080 can slow…

    San Francisco, California and other locations

  • Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)

    Sorry, in progress, not accepting new patients

    The purpose of this study is to compare the effects of three on-line wellness interventions for improving physical and cognitive function and brain connectivity in adults who are at least 55 years old and are experiencing symptoms of memory and/or…

    San Francisco, California

  • Living Alone in Old Age With Cognitive Impairment

    Sorry, in progress, not accepting new patients

    The purpose of this study is to better understand the experience of living alone in older age with cognitive impairment. We recruit adults 55+ living alone with cognitive impairment such as Alzheimer's disease or mild cognitive impairment. This…

    San Francisco, California

  • Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey

    Sorry, in progress, not accepting new patients

    There is a major unmet need for timely, non-invasive, and low-burden evaluation of patients presenting with mild cognitive impairment (MCI) and dementia. MCI impacts 12-18% of people in the United States over age 60 years (Alzheimer's Association.…

    San Francisco, California and other locations

Our lead scientists for Mild Cognitive Impairment research studies include .

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