Neuroimaging clinical trials at UCSF
11 in progress, 9 open to eligible people
Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults
open to eligible people ages 60-120
Assess the impact of a remote, app-delivered digital meditation intervention on emotional well-being of lonely older adults. Neuroimaging, electrophysiological (EEG), and autonomic physiology will be used to assess the neural correlates of the…
San Francisco, California
Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) for Response Monitoring to Neoadjuvant Abiraterone
open to eligible people ages 18 years and up
This study will evaluate the use of hyperpolarized 13C MRI (HP 13C MRI) and the HP-derived 13C pyruvate-to-lactate conversion rate constant (kPL) as an early response biomarker in men with treatment-naïve, high-risk, localized or locally advanced…
San Francisco, California
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer
open to eligible males ages 18 years and up
This is a prospective imaging study evaluating the utility of baseline metabolic MR imaging as a diagnostic and response monitoring tool in patients with advanced prostate cancer. Preliminary pre-clinical and clinical data demonstrates the ability…
San Francisco, California
Neural and Physiological Correlates of Psychedelic Sub-states
open to eligible people ages 21-70
The main purpose of this study is to gain a better understanding of the distinct mental states and physical reactions that can arise during a psychedelic experience. By repeatedly assessing the same participants in an MRI while under the effects of…
San Francisco, California
Neuroimaging Biomarkers for Predicting rTMS Response in OCD
open to eligible people ages 18-80
This study evaluates an accelerated schedule of theta-burst stimulation using a Transcranial Magnetic Stimulation (TMS) device for treatment-resistant Obsessive Compulsive Disorder (OCD). In a randomized fashion, half the participants will receive…
Stanford, California
Alzheimer's Disease Neuroimaging Initiative 4
open to eligible people ages 55-90
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2,…
San Francisco, California and other locations
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
open to eligible people ages 65 years and up
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally…
San Francisco, California and other locations
Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver Disease
open to eligible people ages 18 years and up
The recent development of dissolution dynamic nuclear polarization (DNP) technology for hyperpolarized (HP) 13C imaging offers a promising new avenue for non-invasively accessing fundamental metabolic changes associated with the progression of fatty …
San Francisco, California
Magnetic Resonance Imaging in Radiotherapy for Breast Cancer
open to eligible people ages 18 years and up
This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.
San Francisco, California
Neuroimaging Study of Open-label Placebo in Depressed Adolescents
Sorry, in progress, not accepting new patients
Major depressive disorder (MDD) is the current leading cause of disability worldwide and adolescence is an especially vulnerable period for the onset of depression. Non-pharmacologic approaches are particularly attractive as treatment of adolescent…
San Francisco, California
4 Repeat Tauopathy Neuroimaging Initiative
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this…
San Francisco, California and other locations
Our lead scientists for Neuroimaging research studies include Lisa Singer Scott Mackin, Ph.D. Michael Ohliger, MD Robin Carhart-Harris, PhD Tony T Yang, MD, PhD Ivan de Kouchkovsky Andrew Lee Lorenzo Pasquini Adam Boxer, MD, PhD.
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