for people ages 18 years and up (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Lisa Singer, MD, PhD
Headshot of Lisa Singer
Lisa Singer



This is a single-center, prospective pilot study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatment (RT) for breast cancer.

Official Title

Magnetic Resonance Imaging in RadiotheRapy fOr bReast Cancer (MIRROR): A Pilot Study of MRI Simulation



  1. To determine feasibility of acquiring MRI simulation prior to RT planning.


  1. To determine change in target volume with MRI simulation compared to Computerized tomography (CT) simulation.

OUTLINE: MRI simulation will be performed once at baseline. There is no follow up planned for study purposes. Patients will be followed as part of their regular clinical care.


Breast Cancer, Imaging, Breast Neoplasms, Magnetic Resonance Imaging Simulation


You can join if…

Open to people ages 18 years and up

  1. Participants with an Eastern Cooperative Oncology Group (ECOG) performance status <=2 (or Karnofsky ≥>=60%, see Appendix A).
  2. Participants with the ability to understand and the willingness to sign a written informed consent document.
  3. Participants may separately enroll on therapeutic clinical trials when they enroll on this trial. Note: All interventions on this protocol are standard of care, so enrollment on other therapeutic protocols is allowed at the discretion of the treating physician.
  4. Patients must have pathologically confirmed invasive or in situ breast cancer.
  5. Patients must have tumors in which adjuvant breast radiotherapy following breast conserving surgery is indicated, as determined by the treating physician.
  6. Patients must be female. Note: Male patients are excluded due to the rarity of male breast cancer and difficulty in pursuing breast conserving surgery for male patients.

You CAN'T join if...

  1. Participants with a contraindication to MRI per the MRI checklist.
  2. Patients with breast tumor or tumor bed not visualized at CT or MRI during RT planning.


  • UCSF accepting new patients
    San Francisco California 94143 United States

Lead Scientist at UCSF

  • Lisa Singer, MD, PhD
    Dr. Singer is an attending physician and Assistant Professor in Radiation Oncology at UCSF, where she specializes in the use of radiation to treat breast cancer, thoracic cancer, and ventricular tachycardia. She also serves as Clinical Magnetic Resonance Imaging (MRI) Director in Radiation Oncology and is board-certified in both radiation oncology and MRI safety.


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 20 study participants
Last Updated