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Opioid Use clinical trials at UCSF
5 in progress, 4 open to eligible people

  • Acute Pain Management in Patients on Opioid Replacement Therapy

    open to eligible people ages 18-60

    This is an outpatient randomized within subject placebo-controlled human laboratory investigation of analgesia (as assessed with quantitative sensory testing; QST) from ketamine alone and in combination with hydromorphone in buprenorphine maintained participants. The goals of this project are to characterize the analgesic, subjective, and physiologic effects of ketamine combined with hydromorphone in patients on buprenorphine maintenance for opioid use disorder.

    San Francisco, California

  • Empower Opioid Misuse & Chronic Pain

    open to eligible people ages 18-75

    This study evaluates the effects of peripheral nerve stimulation on opioid craving and use and pain in participants with chronic non-cancer pain (NCP) and opioid misuse. Participants will be randomized to receive the active or sham control treatment for the duration of the study.

    San Francisco, California

  • Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial

    open to eligible people ages 18 years and up

    The Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial is a single center, double-blind, randomized, active-comparator controlled clinical trial to assess the analgesic efficacy of intercostal nerve block by Liposomal Bupivacaine versus Standard Bupivacaine in subjects undergoing lung resection by robotic or video-assisted thoracoscopic surgery.

    San Francisco, California

  • Stimulant Oxytocin Study

    open to eligible people ages 18 years and up

    This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with stimulant use disorders and enrolled in opioid replacement therapy (ORT) program for co-occurring opioid use disorder (OUD).

    San Francisco, California and other locations

  • PCORnet Opioid Surveillance Study

    Sorry, in progress, not accepting new patients

    The overarching objective of this project is to demonstrate and assess the feasibility of using the Patient Centered Outcomes Research Network (PCORnet) Common Data Model for opioid surveillance to complement existing and support future initiatives. This project will characterize risk factors, processes, and outcomes related to opioid use, misuse, and abuse. It will quantify the utility of data stored in the PCORnet Common Data Model format stewarded by healthcare organizations participating in PCORnet.

    San Francisco, California and other locations

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