Opioid Use clinical trials at UCSF
6 in progress, 4 open to eligible people
Opioid use includes taking pain-relieving drugs that may lead to addiction. UCSF is comparing injectable and oral buprenorphine for treating opioid use disorder. Another trial tests naltrexone's ability to prevent fentanyl overdoses. UCSF is also examining retention in treatment by comparing office-based methadone with buprenorphine.
Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
open to eligible people ages 18 years and up
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence…
San Francisco, California and other locations
Naltrexone for Overdose Prevention
open to eligible people ages 18 years and up
The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine). The main questions it aims to answer are: What are the challenges…
San Francisco, California
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
open to eligible people ages 18-99
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors…
San Francisco, California and other locations
Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
open to eligible people ages 18 years and up
The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social…
San Francisco, California
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
Sorry, not yet accepting patients
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of…
San Francisco, California
Pain and Opioids: Integrated Treatment In Veterans
Sorry, in progress, not accepting new patients
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD). We seek to: (1) examine the efficacy of an integrated treatment to reduce pain interference (Acceptance and …
San Francisco, California and other locations
Our lead scientists for Opioid Use research studies include Andy Tompkins, MD Ayesha Appa Melanie F Molina, MD, MAS Ralph Wang, MD, MAS Paula Lum, MD.
Last updated: