Opioid Use clinical trials at UCSF

7 in progress, 3 open to eligible people

Opioid use refers to taking drugs that can become addictive. UCSF is testing different treatments for opioid use disorder. One clinical trial compares oral and injectable forms of buprenorphine. Another study evaluates methadone and buprenorphine given in a doctor's office. There's also research on how eye changes might reflect opioid exposure levels.

Showing trials for

  • Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

    open to eligible people ages 18 years and up

    VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence…

    San Francisco, California and other locations

  • Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

    open to eligible people ages 18-99

    The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors…

    San Francisco, California and other locations

  • Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

    open to eligible people ages 40-60

    This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a…

    San Francisco, California

  • Naloxone for Opioid Associated Out of Hospital Cardiac Arrest

    Sorry, not yet accepting patients

    The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of…

    San Francisco, California

  • Naltrexone for Overdose Prevention

    Sorry, not yet accepting patients

    The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine). The main questions it aims to answer are: What are the challenges…

    San Francisco, California

  • Pain and Opioids: Integrated Treatment In Veterans

    Sorry, in progress, not accepting new patients

    This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD). We seek to: (1) examine the efficacy of an integrated treatment to reduce pain interference (Acceptance and …

    San Francisco, California and other locations

  • Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

    Sorry, not yet accepting patients

    The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social…

    San Francisco, California

Our lead scientists for Opioid Use research studies include .

Last updated: