Progressive Supranuclear Palsy clinical trials at UCSF
9 in progress, 3 open to eligible people
FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)
open to eligible people ages 50-80
PROSPER trial is a trial to assess the efficacy of FNP-223 in slowing disease progression in participants with PSP as measured by the PSP Rating Scale (PSPRS) over 52 weeks and to assess the safety and tolerability of FNP-223 for 52 weeks in…
San Francisco, California and other locations
Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)
open to eligible people ages 18 years and up
Prior research has identified profound sleep disruption in individuals with PSP. Not only were these individuals sleeping relatively short periods at night, they were also not recuperating lost sleep during the day. Research also showed the relative …
San Francisco, California
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
open to eligible people ages 18 years and up
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium…
San Francisco, California and other locations
TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
Sorry, in progress, not accepting new patients
This is a Phase 2a study to assess the safety and tolerability of TPN-101 patients with PSP.
San Francisco, California and other locations
AMX0035 and Progressive Supranuclear Palsy
Sorry, in progress, not accepting new patients
A35-009 (ORION) is a Phase 2b/3 trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of randomized, double blind placebo controlled phases, followed by an optional open-label…
San Francisco, California and other locations
Parkinson's and Zoledronic Acid
Sorry, in progress, not accepting new patients
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 …
San Francisco, California and other locations
4 Repeat Tauopathy Neuroimaging Initiative
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this…
San Francisco, California and other locations
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
Sorry, in progress, not accepting new patients
The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug trials. The study will…
San Francisco, California and other locations
Automated Imaging Differentiation of Parkinsonism
Sorry, in progress, not accepting new patients
The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical…
San Francisco, California and other locations
Our lead scientists for Progressive Supranuclear Palsy research studies include Thomas Neylan, MD Courtney Lane-Donovan, MD, PhD Adam Boxer, MD, PhD Howie Rosen, MD.
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